Key Documents

Nefazodone Hydrochloride

Name: Nefazodone Hydrochloride
Brand: MM

Synonym(s):

Nefazodone Hydrochloride, 5-HT _2A Serotonin Receptor Antagonist, Nefazodone, BMY-13754, MJ-13754-1, Serzone, 5-HT_2A Serotonin Receptor Antagonist, Nefazodone, BMY-13754, MJ-13754-1, Serzone

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About This Item

Empirical Formula (Hill Notation):

C₂₅H₃₂ClN₅O₂ · xHCl

CAS Number:

82752-99-6

Molecular Weight:

470.01 (free base basis)

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD00935760

Assay:

≥99% (HPLC)

Form:

solid

Storage condition:

OK to freeze, protect from light

Pricing and availability is not currently available.

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Properties

assay

≥99% (HPLC)

Quality Segment

100

form

solid

potency

26 nM K_i

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

white

solubility

ethanol: 10 mM, DMSO: 25 mM

storage temp.

2-8°C

SMILES string

Clc1cc(ccc1)N2CCN(CC2)CCC[n]3nc([n]([c]3=O)CCOc4ccccc4)CC.Cl

InChI

1S/C25H32ClN5O2.ClH/c1-2-24-27-31(25(32)30(24)18-19-33-23-10-4-3-5-11-23)13-7-12-28-14-16-29(17-15-28)22-9-6-8-21(26)20-22;/h3-6,8-11,20H,2,7,12-19H2,1H3;1H

InChI key

DYCKFEBIOUQECE-UHFFFAOYSA-N

Description

General description

A potent 5-HT_2A receptor antagonist (K_d = 26 nM), with moderate affinity for the alpha1-adrenergic receptor (K_d = 48 nM) and 5-HT_1A receptor (K_d = 80 nM). Originally developed as a clinical antidepressant but discontinued in 2004, nefazodone (Serzone) still remains a specific inhibitor of certain serotonergic pathways. Nefazodone also has been reported to induce mitochondrial dysfuntion.

Other Notes

Kim, J.-A. et al. 2012. Toxicol. Lett.214, 175.
Cusack, B. et al. 1994. Psychopharmacol.114, 559.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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This Item	1457902	N5536	508146
Sigma-Aldrich 508148 Nefazodone Hydrochloride	USP 1457902 Nefazodone hydrochloride	Sigma-Aldrich N5536 Nefazodone hydrochloride	Sigma-Aldrich 508146 WAY-100635 Maleate
description -	description United States Pharmacopeia (USP) Reference Standard	description ≥98% (HPLC), solid	description -
form solid	form -	form solid	form solid
assay ≥99% (HPLC)	assay -	assay ≥98% (HPLC)	assay ≥97% (HPLC)
Quality Level 100	Quality Level -	Quality Level 100	Quality Level 100
manufacturer/tradename Calbiochem^®	manufacturer/tradename USP	manufacturer/tradename -	manufacturer/tradename Calbiochem^®
storage temp. 2-8°C	storage temp. -	storage temp. -	storage temp. 2-8°C
solubility ethanol: 10 mM, DMSO: 25 mM	solubility -	solubility DMSO: ≥10 mg/mL, H₂O: insoluble	solubility water: 50 mM

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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