A potent agonist selective for neuronal nAChRs (Ki = 2, 5890, 480, 329, and 492 nM at α4β2, α7, α3β4, α6/α4β4, α1β1γδ, respectively). Clinically used as a smoking cessation medicine and often used in addiction studies.
Biochem/physiol Actions
Primary Target nAChR
Reversible: yes
Target Ki: 2, 5890, 480, 329, and 492 nM at &alpha
Warning
Toxicity: Toxic (F)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Chen, Y., et al., 2012. Br J Pharmacol.165, 1006. West, R., 2011, N. Engl. J. Med.365, 1193.
Happe, K., et al., 1994. Neurosci.62, 929.
Reavill, C. et al., 1990. Neuropharmacol.29, 619.
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Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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