233183

Clodronate disodium Salt

≥97% (titration), bone resorption inhibitor, solid

• Synonym(s): Clodronate, Disodium Salt, Clodronate, Disodium, Tetrahydrate, Dichloromethylene-bisphosphonate, Disodium Tetrahydrate
• Empirical Formula (Hill Notation): CH₂Cl₂Na₂O₆P₂ · 4H₂O
• CAS Number: 88416-50-6
• Molecular Weight: 360.92
• MDL number: MFCD02940846
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥97% (titration)
• Form: solid
• Storage condition: OK to freeze, desiccated (hygroscopic)

Properties

• Product Name: Clodronate, Disodium Salt, A non-amino, chloro-containing bisphosphonate that acts as a potent inhibitor of osteoclast-mediated bone resorption.
• Quality Segment: 100
• description: Merck USA index - 14, 2371
• assay: ≥97% (titration)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, desiccated (hygroscopic)
• color: white
• solubility: water: 1 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• SMILES string: [Na+].[Na+].[P](=O)([O-])(O)C([P](=O)([O-])O)(Cl)Cl.O.O.O.O
• InChI: 1S/CH4Cl2O6P2.2Na.4H2O/c2-1(3,10(4,5)6)11(7,8)9;;;;;;/h(H2,4,5,6)(H2,7,8,9);;;4*1H2/q;2*+1;;;;/p-2
• InChI key: XWHPUCFOTRBMGS-UHFFFAOYSA-L

Description

General description

A non-amino, chloro-containing bisphosphonate that acts as a potent inhibitor of osteoclast-mediated bone resorption. It is metabolized into a non-hydrolyzable ATP analog in osteoclasts and macrophages, and induces apoptosis by inhibiting mitochondrial function. An efficient metal chelator that inhibits invasion, adhesion, and migration of PC-3 prostate cancer cells (IC₅₀ = 100 nM).

A non-amino, chloro-containing, bisphosphonate that acts as a potent inhibitor of osteoclast-mediated bone resorption. Metabolized to a non-hydrolyzable ATP analog in osteoclasts and macrophages that induces apoptosis by inhibiting mitochondrial function. An efficient metal chelator that inhibits invasion, adhesion and migration of PC-3 prostate cancer cells (IC₅₀ = 100 nM).

Biochem/physiol Actions

Cell permeable: no

Primary Target
Osteoclast-mediated bone resorption

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 100 nM inhibiting invasion, adhesion, and migration of PC-3 prostate cancer cells

Other Notes

Lehenkari, P.P., et al. 2002. Mol. Pharmacol.61, 1255.
Virtanen, S.S., et al. 2002. Cancer Res.62, 2708.
Smith, R., et al. 1971. Lancet1, 945.
Fleisch, H., et al. 1969. Nature223, 211.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable