Trimethylene oxide is a strained cyclic ether which can be used to replace carbonyl / gem-dimethyl groups during molecular modelling of bioactive molecules.[1]
It can be incorporated in various bioactive molecule and drug substances for its improved physicochemical properties, via novel C-H activation methods.[2][3][4][5]
Trimethylene oxide can also be used in the synthesis of poly(trimethylene oxide) and related polymer electrolytes.[6][7][8]
Photoinduced reactions of isatin and N-methyl-1,3,4-isoquinolinetrione with bicycloalkylidenes such as bicyclopropylidene, cyclopropylidenecyclobutane, cyclopropylidenecyclohexane and bicyclohexylidene were investigated. The reactions gave spirooxetanes as the major products derived from the [2 + 2] photocycloaddition pathway via 1,4-biradical recombination. Unusual products including the
Radical ?-C? H Hydroxyalkylation of Ethers and Acetal.
Yoshimitsu T, et al.
The Journal of Organic Chemistry, 70(6), 2342-2345 (2005)
Radical addition of ethers to alkenes under dioxygen catalyzed by N-hydroxyphthalimide (NHPI)/Co(OAc)2.
Hirano K, et al.
Tetrahedron Letters, 43(20), 3617-3620 (2002)
Photocatalytic Synthesis of Oxetane Derivatives by Selective C-H Activation.
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