Topiramate (Topamax®) is an antiepileptic medication used as adjunctive and monotherapy in patients with epilepsy and for migraine prophylaxis. A GC-MS assay was developed that was capable of detecting topiramate plasma concentrations following a single rectal or oral dose administration.
Journal of pharmaceutical sciences, 70(6), 618-620 (1981-06-01)
Carbamazepine and cyheptamide have certain stereochemical features in common with phenytoin; when superimposed, two bulky hydrophobic groups in each permit the approximate apposition of two electron donor atoms. The anticonvulsant activity of each compound was determined in mice using a
Journal of medicinal chemistry, 27(5), 649-654 (1984-05-01)
The molecular structures of cyheptamide and 3-hydroxy-3- phenacyloxindole were determined by X-ray diffraction methods. The amide group in both compounds exhibits delocalization of the pi-electrons over the three atoms (N, C, and O), while the bond linking the amide to
[Determination of plasma lidocaine by gas-liquid chromatography].
I Saavedra et al.
Revista medica de Chile, 115(7), 661-664 (1987-07-01)
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