F4537
Fibroblast Growth Factor-5 human
recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture, ≥97% (SDS-PAGE and N-terminal analysis)
Synonym(s):
hFGF-5, FGF-5
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About This Item
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biological source
human
Quality Level
recombinant
expressed in E. coli
Assay
≥97% (SDS-PAGE and N-terminal analysis)
form
lyophilized powder
potency
0.1-15.0 ng/mL
mol wt
27 kDa
packaging
pkg of 50 μg
storage condition
avoid repeated freeze/thaw cycles
technique(s)
cell culture | mammalian: suitable
impurities
endotoxin, tested
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... FGF5(2250)
Application
Fibroblast growth factor-5 human has been used for the induction of differentiation in E14Tg2a and 46C parental mouse ES (embryonic stem) cell lines, Fgf4+/- (clone 342) ,Fgf4-/- (clone FD6) ES cells and Erk2+/- ES cells and Erk2-/- ES cell lines.
Biochem/physiol Actions
FGF5 (fibroblast growth factor 5) regulates hair growth cycle, and its inactivation in mice leads to angora phenotype. In the peripheral nervous system, it acts as a muscle-derived trophic factor for motor neurons. In vivo it demonstrates neurotrophic activity, and in vitro it influences astroglial characteristics. It functions as an oncogene in glioblastoma due to its autocrine and paracrine functions. Its expression is elevated in human astrocytic brain tumours, which is linked to increased malignancy. It causes the regression of hair follicles, and thus, controls the length of hair in humans. It might have potential as a therapeutic target to control the growth of eyelashes.
Physical form
Lyophilized from a 0.2 μm filtered solution in 10mM MOPS, 50 mM NaSO4, 0.5 mM EDTA, 0.5 mM DTT and 5% trehalose, pH 7.0 containing 50 μg BSA per 1 μg cytokine.
Analysis Note
The biological activity is tested in culture with quiescent NR6R-3T3 fibroblasts.
Storage Class Code
11 - Combustible Solids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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Claire A Higgins et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(29), 10648-10653 (2014-07-06)
Mechanisms that regulate the growth of eyelashes have remained obscure. We ascertained two families from Pakistan who presented with familial trichomegaly, or extreme eyelash growth. Using a combination of whole exome sequencing and homozygosity mapping, we identified distinct pathogenic mutations
Fibroblast growth factors (FGFs).
Vainikka, S., et al. et al.
Guidebook to Cytokines and Their Receptors, 214-214 (1994)
Ahlam I Salameh et al.
The Journal of physiology, 595(1), 93-124 (2016-06-30)
A polymorphism of human AE3 is associated with idiopathic generalized epilepsy. Knockout of AE3 in mice lowers the threshold for triggering epileptic seizures. The explanations for these effects are elusive. Comparisons of cells from wild-type vs. AE3 The anion exchanger
M Klagsbrun
Progress in growth factor research, 1(4), 207-235 (1989-01-01)
This article summarizes the structural and biological properties of the family of fibroblast growth factors (FGF). Basic FGF (bFGF) and acidic FGF (aFGF) are the best characterized members of this family. bFGF and aFGF are potent modulators of cell proliferation
S Allerstorfer et al.
Oncogene, 27(30), 4180-4190 (2008-03-26)
Fibroblast growth factor 5 (FGF5) is widely expressed in embryonic but scarcely in adult tissues. Here we report simultaneous overexpression of FGF5 and its predominant high-affinity receptor (FGFR1 IIIc) in astrocytic brain tumour specimens (N=49) and cell cultures (N=49). The
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