Z0127

Zatebradine hydrochloride

≥98% (HPLC), powder

• 동의어(들): 7,8-Dimethoxy-3-[3-[-N-[2-(3,4 dimethoxyphenyl)ethyl]-N-methylamino]propyl]-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one hydrochloride, UL-FS49
• 실험식(Hill 표기법): C₂₆H₃₇ClN₂O₅
• CAS Number: 91940-87-3
• Molecular Weight: 493.04
• MDL number: MFCD06798356
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24724672
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 저장 조건: desiccated
• 색상: white
• solubility: H₂O: >10 mg/mL
• 주관자: Boehringer Ingelheim
• 저장 온도: 2-8°C
• SMILES string: Cl[H].COc1ccc(CCN(C)CCCN2CCc3cc(OC)c(OC)cc3CC2=O)cc1OC
• InChI: 1S/C26H36N2O5.ClH/c1-27(13-9-19-7-8-22(30-2)23(15-19)31-3)11-6-12-28-14-10-20-16-24(32-4)25(33-5)17-21(20)18-26(28)29;/h7-8,15-17H,6,9-14,18H2,1-5H3;1H
• InChI key: ZRNKXJHEQKMWCH-UHFFFAOYSA-N

설명

애플리케이션

Zatebradine hydrochloride has been used:

• as an I_f blocker to study its effects on cardiomyocyte clusters (CMCs) [1]
• as a hyperpolarization-activated and cyclic nucleotide-gated (HCN) channel inhibitor to study its effects on viability of degenerating rod or cone photoreceptors in mice [2]
• as a bradycardiac agent to study its effects on tachycardia and elevated temperature in fish [3]

생화학적/생리학적 작용

HCN channel blocker: blocker of neuronal I_h, related cardiac I_f channels and ATP-sensitive K_ir channels.

Zatebradine is a bradycardiac agent.[4]

특징 및 장점

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Boehringer Ingelheim. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)