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W4394

Sigma-Aldrich

Withaferin A

≥95% (HPLC)

동의어(들):

5,6-Epoxy-4,27-dihydroxy-1-oxowitha-2,24-dienolide, Withaferine A

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크기 선택

5 MG
₩924,564

₩924,564

구입 가능 여부는 고객센터에 문의하십시오.
벌크 견적 요청
모든 사진(1)

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5 MG
₩924,564

About This Item

실험식(Hill 표기법):
C28H38O6
CAS Number:
5119-48-2
Molecular Weight:
470.60
MDL number:
MFCD10687098
UNSPSC 코드:
12352211
PubChem Substance ID:
329830709
NACRES:
NA.77

₩924,564

구입 가능 여부는 고객센터에 문의하십시오.
벌크 견적 요청

생물학적 소스

plant (Withania somnifera)

Quality Level

200

분석

≥95% (HPLC)

양식

powder

mp

252-253 °C

작용기

epoxy
ketone

배송 상태

ambient

저장 온도

2-8°C

SMILES string

C[C@H]([C@H]1CC(C)=C(CO)C(=O)O1)[C@H]2CC[C@H]3[C@@H]4C[C@H]5O[C@]56[C@@H](O)C=CC(=O)[C@]6(C)[C@H]4CC[C@]23C

InChI

1S/C28H38O6/c1-14-11-21(33-25(32)17(14)13-29)15(2)18-5-6-19-16-12-24-28(34-24)23(31)8-7-22(30)27(28,4)20(16)9-10-26(18,19)3/h7-8,15-16,18-21,23-24,29,31H,5-6,9-13H2,1-4H3/t15-,16-,18+,19-,20-,21+,23-,24+,26+,27-,28+/m0/s1

InChI key

DBRXOUCRJQVYJQ-CKNDUULBSA-N

관련 카테고리

애플리케이션

Withaferin A was used to treat HEK293 cells to study its effect on cystic fibrosis inflammation.[1]

생화학적/생리학적 작용

Steroidal lactone that exhibits cytotoxicity towards tumor cells. Protective effects attributed to anti-lipid peroxidative, antioxidant and detoxifying functionality.
Withaferin A is a steroidal lactone that is isolated from the plant Withania somnifera. It has potent anti-inflammatory properties as it inhibits the activation of NF-κ B signaling pathway.[2] The anti-tumor activity of Withaferin A is due to its ability to alter cytoskeletal architecture by binding annexin II and disrupting F actin cross-links.[3] Withaferin A also inhibits angiogenesis by binding to vimentin and F-actin.[4]

제조 메모

Withaferin A yields a clear, colorless solution in methanol at 1 mg/ml.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point (°F)

438.8 °F

Flash Point (°C)

226 °C

가장 최신 버전 중 하나를 선택하세요:

시험 성적서(COA)

Lot/Batch Number
SLCN2765
SLCN0222
SLCM7668
SLCM9129
SLCM8033

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COA 검색

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이미 열람한 고객

Slide 1 of 3

1 of 3

JNK-IN-8 ≥96% (HPLC)

Sigma-Aldrich

SML1246

JNK-IN-8

Mitoxantrone dihydrochloride ≥97% (HPLC)

Sigma-Aldrich

M6545

Mitoxantrone dihydrochloride

Phenylacetic hydrazide 98%

Sigma-Aldrich

P16656

Phenylacetic hydrazide

Silvia D Stan et al.
Nutrition and cancer, 60 Suppl 1, 51-60 (2008-11-15)
Withaferin A (WA) is derived from the medicinal plant Withania somnifera that has been safely used for centuries in the Indian Ayurvedic medicine for treatment of various ailments. We now demonstrate that WA treatment causes G2 and mitotic arrest in
Paola Bargagna-Mohan et al.
Chemistry & biology, 14(6), 623-634 (2007-06-23)
The natural product withaferin A (WFA) exhibits antitumor and antiangiogenesis activity in vivo, which results from this drug's potent growth inhibitory activities. Here, we show that WFA binds to the intermediate filament (IF) protein, vimentin, by covalently modifying its cysteine
Inhibition of NFκB by the natural product Withaferin A in cellular models of Cystic Fibrosis inflammation
Maitra R et al
Journal of Inflammation (London, England), 6, doi: 10-doi: 10 (2009)
Hee Jung Um et al.
Biochemical and biophysical research communications, 427(1), 24-29 (2012-09-18)
Withaferin A, the active component of Withania somnifera, causes cytotoxicity in a variety of tumor cell lines. In this study, we show that withaferin A inhibits constitutive and IL-6-induced phosphorylation of STAT3 (on Tyr705), but not IFN-γ-induced STAT1 phosphorylation. Withaferin
Wim Vanden Berghe et al.
Biochemical pharmacology, 84(10), 1282-1291 (2012-09-18)
Herbal medicine which involves the use of plants for their medicinal value, dates as far back as the origin of mankind and demonstrates an array of applications including cardiovascular protection and anti-cancer activities, via antioxidant, anti-inflammatory and metabolic activities. Even
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질문

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  1. How does the storage temperature relate to shipping conditions?

    1 답변

    1. The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment.

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  2. What is the solution stability of Product W4394, Withaferin A?

    1 답변

    1. Sigma-Aldrich does not test the Product W4394, Withaferin A, for solution stability. Information in our files indicates that although it is best to use freshly prepared solution when possible. However, if stock solutions must be stored, we would recommend they be stored in frozen aliquots at -20°C or below for about one month.

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  3. What is the Department of Transportation shipping information for this product?

    1 답변

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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  4. How does one solubilize Product W4394, Withaferin A?

    1 답변

    1. Sigma-Aldrich tests Product W4394, Withaferin A, for solubility using methanol at a concentration of 1 mg/mL. Information in our files indicates that it is also soluble in DMSO and ethanol.

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