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Merck
모든 사진(1)

주요 문서

T8806

Sigma-Aldrich

Thymopentin

≥97% (HPLC)

동의어(들):

TP5, Arg-Lys-Asp-Val-Tyr

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About This Item

실험식(Hill 표기법):
C30H49N9O9
CAS Number:
Molecular Weight:
679.76
MDL number:
UNSPSC 코드:
12352209
PubChem Substance ID:
NACRES:
NA.26

제품명

Thymopentin, ≥97% (HPLC)

Quality Level

분석

≥97% (HPLC)

양식

powder

색상

white

응용 분야

cell analysis

저장 온도

−20°C

SMILES string

CC(C)[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O

InChI

1S/C30H49N9O9/c1-16(2)24(28(46)38-22(29(47)48)14-17-8-10-18(40)11-9-17)39-27(45)21(15-23(41)42)37-26(44)20(7-3-4-12-31)36-25(43)19(32)6-5-13-35-30(33)34/h8-11,16,19-22,24,40H,3-7,12-15,31-32H2,1-2H3,(H,36,43)(H,37,44)(H,38,46)(H,39,45)(H,41,42)(H,47,48)(H4,33,34,35)/t19-,20-,21-,22-,24-/m0/s1

InChI key

PSWFFKRAVBDQEG-YGQNSOCVSA-N

Amino Acid Sequence

Arg-Lys-Asp-Val-Tyr

일반 설명

Thymopentin (TP5) is a pentapeptide produced by the epithelial cells of the thymic cortex and medulla. It consists of thymosin α1 (Tα1).

생화학적/생리학적 작용

Thymopentin (TP5) is an immunomodulator, resembling the active site of the thymopoietin. TP5 stimulates cellular immune responses such as T-cell formation, natural killer (NK) cell and macrophage activation, generation of cytokines, and activation of B-cell for antibody production. It also mimics the polypeptide environment of the thymus. TP5 is used to treat conditions like immune deficiency, autoimmune diseases, infections, and cancers. It has a short half-life and is rapidly metabolized in the gastrointestinal tract.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)


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문서 라이브러리 방문

G Goldstein et al.
Survey of immunologic research, 4 Suppl 1, 1-10 (1985-01-01)
Thymopoietin is a polypeptide hormone of the thymus consisting of 49 amino acids. The pentapeptide thymopentin (TP-5) Arg-Lys-Asp-Val-Tyr, corresponding to amino acids 32-36 of thymopoietin, appears to represent the active site of thymopoietin in that it has all the biological
Jing Gao et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 36(4-5), 572-579 (2009-01-13)
Thymopentin (TP5), a synthetic pentapeptide, has been used in clinic as a modulator for immunodeficiences through intramuscular administration. The purpose of this study was to design and evaluate dry powder inhalations (DPIs) for pulmonary delivery of TP5. Dry powder inhalations
Yan Zhang et al.
International journal of pharmaceutics, 386(1-2), 15-22 (2009-11-10)
Copolymers were synthesized by ring opening polymerization of l- or d-lactide in the presence of dihydroxyl PEG with molar mass of 6000, 12,000 and 20,000, using zinc lactate as catalyst. Bioresorbable hydrogels were obtained by mixing PLLA-PEG-PLLA and PDLA-PEG-PDLA aqueous
Lei Wang et al.
International journal of pharmaceutics, 375(1-2), 1-7 (2009-05-16)
The present work describes a new dry powder containing thymopentin (TP5) suitable for inhalation. A total of 21 dry powders were produced by co-spray drying TP5 with lactose or mannitol as a bulking agent, leucine as a dispersibility enhancer and
V K Singh et al.
Immunologic research, 17(3), 345-368 (1998-06-25)
Splenopentin (SP-5, Arg-Lys-Glu-Val-Tyr) and thymopentin (TP-5, Arg-Lys-Asp-Val-Tyr) are synthetic immunomodulating peptides corresponding to the region 32-34 of a splenic product called splenin (SP) and the thymic hormone thymopoietin (TP), respectively. TP was originally isolated as a 5-kDa (49-amino acids) protein

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