모든 사진(1)
About This Item
실험식(Hill 표기법):
C30H49N9O9
CAS Number:
Molecular Weight:
679.76
MDL number:
UNSPSC 코드:
12352209
PubChem Substance ID:
NACRES:
NA.26
추천 제품
제품명
Thymopentin, ≥97% (HPLC)
Quality Level
분석
≥97% (HPLC)
양식
powder
색상
white
응용 분야
cell analysis
저장 온도
−20°C
SMILES string
CC(C)[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O
InChI
1S/C30H49N9O9/c1-16(2)24(28(46)38-22(29(47)48)14-17-8-10-18(40)11-9-17)39-27(45)21(15-23(41)42)37-26(44)20(7-3-4-12-31)36-25(43)19(32)6-5-13-35-30(33)34/h8-11,16,19-22,24,40H,3-7,12-15,31-32H2,1-2H3,(H,36,43)(H,37,44)(H,38,46)(H,39,45)(H,41,42)(H,47,48)(H4,33,34,35)/t19-,20-,21-,22-,24-/m0/s1
InChI key
PSWFFKRAVBDQEG-YGQNSOCVSA-N
Amino Acid Sequence
Arg-Lys-Asp-Val-Tyr
일반 설명
Thymopentin (TP5) is a pentapeptide produced by the epithelial cells of the thymic cortex and medulla. It consists of thymosin α1 (Tα1).[1]
생화학적/생리학적 작용
Thymopentin (TP5) is an immunomodulator, resembling the active site of the thymopoietin. TP5 stimulates cellular immune responses such as T-cell formation,[1] natural killer (NK) cell and macrophage activation,[2] generation of cytokines, and activation of B-cell for antibody production. It also mimics the polypeptide environment of the thymus.[1] TP5 is used to treat conditions like immune deficiency, autoimmune diseases, infections, and cancers. It has a short half-life and is rapidly metabolized in the gastrointestinal tract.[3]
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
Antonia Patruno et al.
Nitric oxide : biology and chemistry, 27(3), 143-149 (2012-06-23)
While thymopentin has been used for many years in the experimental treatment of Sézary syndrome (SS), a rare and very aggressive lymphoma, its mechanism of action is still not known. Herein we show that this peptide acts as an inhibitor
Bo Yang et al.
Hematological oncology, 30(3), 115-122 (2012-09-14)
The elderly population is susceptible to haematological malignancies, and these elderly patients are intolerant to cytotoxic drugs. Therefore, the exploration of a safe and reliable strategy exclusive of chemotherapy is critical in improving the prognosis of elderly patients with haematological
Wendy B London et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 29(24), 3286-3292 (2011-07-20)
Survival after neuroblastoma relapse is poor. Understanding the relationship between clinical and biologic features and outcome after relapse may help in selection of optimal therapy. Our aim was to determine which factors were significantly predictive of postrelapse overall survival (OS)
E Sundal et al.
Arzneimittel-Forschung, 44(10), 1145-1149 (1994-10-01)
Although the etiology of rheumatoid arthritis (RA) is unknown, there is solid evidence that immunological factors play a pivotal role in its pathogenesis. It seems that a hyporeactivity of local (intraarticular) T-suppressor cells would permit an excessive immune response that
Elke Wolf et al.
The Cochrane database of systematic reviews, (2)(2), CD003993-CD003993 (2011-02-18)
Purified thymus extracts (pTE) and synthetic thymic peptides (sTP) are thought to enhance the immune system of cancer patients in order to fight the growth of tumour cells and to resist infections due to immunosuppression induced by the disease and
활성 필터
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
고객지원팀으로 연락바랍니다.
