추천 제품
형태
powder
재고 정보
not available in USA
pH
4.8
solubility
H2O: soluble (stable at pH 4-5 if stored frozen)
strong acid or alkaline solutions: unstable (destroyed by boiling at pH 2.)
저장 온도
2-8°C
SMILES string
OC[C@@]1(O)[C@H]2OC3(O)OC1C4[C@@H](O)NC(=N)NC4([C@@H]2O)[C@@H]3O
InChI
1S/C11H17N3O8/c12-8-13-6(17)2-4-9(19,1-15)5-3(16)10(2,14-8)7(18)11(20,21-4)22-5/h2-7,15-20H,1H2,(H3,12,13,14)/t2?,3-,4?,5+,6-,7+,9+,10?,11?/m1/s1
InChI key
CFMYXEVWODSLAX-IXUBDLNJSA-N
유전자 정보
rat ... Scnn1g(24768)
애플리케이션
Tetrodotoxin has been used to study its effects on microglial functions in rats2. This toxin has also been used to inactivate lateral magnocellular nucleus of the nidopallium (LMAN) in juvenile zebra finch. This study reported that the toxin causes a decrease in sequence and acoustic variability which result in the production of a stereotyped song by the motor pathway3.
생화학적/생리학적 작용
Reversible, selective blocker of Na+ channels; blocks propagation of impulses in excitable membranes. Used to characterize sodium channels in excitable membranes and to study the role of sodium channels in normal physiology and disease.
포장
Vial contains 1 mg of tetrodotoxin and approx. 5 mg citrate buffer, pH 4.8.
제조 메모
The product is water soluble and stable at pH 4-5 if it is stored frozen. It is unstable in strong acid and alkaline solutions and is rapidly destroyed by boiling at pH 2 and below.
신호어
Danger
유해 및 위험 성명서
예방조치 성명서
Hazard Classifications
Acute Tox. 1 Oral
Storage Class Code
6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Thomas C Jaramillo et al.
Autism research : official journal of the International Society for Autism Research, 10(1), 42-65 (2016-08-06)
Mutations/deletions in the SHANK3 gene are associated with autism spectrum disorders and intellectual disability. Here, we present electrophysiological and behavioral consequences in novel heterozygous and homozygous mice with a transcriptional stop cassette inserted upstream of the PDZ domain-coding exons in
Miriam Michel et al.
Scientific reports, 9(1), 11888-11888 (2019-08-17)
Assessment of left ventricular mass (LVM) is important in the evaluation of patients with congenital heart disease (CHD) and cardiac magnetic resonance imaging (CMR) is the gold standard. Recent software allows LVM calculation by real-time 3-dimensional echocardiography (RT3DE). We investigated
Hao Yang et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 27(8), 1467-1482 (2019-06-04)
Irreversible neuron loss following spinal cord injury (SCI) usually results in persistent neurological dysfunction. The generation of autologous neural stem cells (NSCs) holds great potential for neural replenishment therapies and drug screening in SCI. Our recent studies demonstrated that mature
Scott R Burks et al.
Theranostics, 9(19), 5517-5531 (2019-09-20)
Pulsed focused ultrasound (pFUS) technology is being developed for clinical neuro/immune modulation and regenerative medicine. Biological signal transduction of pFUS forces can require mechanosensitive or voltage-gated plasma membrane ion channels. Previous studies suggested pFUS is capable of activating either channel
Jie Zhang et al.
Acta biochimica et biophysica Sinica, 51(6), 562-570 (2019-05-30)
The protein voltage-gated sodium channel Nav1.5 is highly upregulated in various types of cancer and, in general, promotes cancer cell invasiveness and metastatic progression. A previous study found that Nav1.5 was highly expressed in poorly differentiated oral squamous cell carcinoma
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