추천 제품
product name
Tetanus toxin from Clostridium tetani,
분자량
150 kDa (heavy chain (100 kDa) and a light chain (50 kDa) connected through an interchain disulfide bond)
Quality Level
solubility
H2O: soluble
저장 온도
2-8°C
유전자 정보
Clostridium tetani E88 ... tetX(1061100)
일반 설명
Tetanus toxin is also known as tetanospasmin. It is a 150-kDa protein, produced by Clostridium tetani. This protein consists of a light and a heavy chain.
애플리케이션
Tetanus toxin from Clostridium tetani has been used as the exocytosis inhibitor/Golgi-dependent secretion to examine whether secretory carrier membrane protein (SCAMP5) stimulated α-synuclein secretion via the conventional Golgi-dependent pathway. It has also been used in peripheral blood mononuclear cells (PBMCs) culture for T cell proliferation screening.
Tetanus toxin from Clostridium tetani has been used to inhibit vesicular release in Pannexin 1-transfected Neuro2A cells1.
생화학적/생리학적 작용
Binds to polysialogangliosides acceptors on surface of all peripheral presynaptic nerve terminals. Internalized by receptor-mediated endocytosis and carried to spinal cord and brain by transsynaptic retrograde transport. Blocks the release of glycine from inhibitory interneurons of the spinal cord. Cleaves synaptobrevin (VAMP-2), and blocks synaptic vesicle exocytosis in vivo.
Tetanus toxin can cause spastic paralysis.
제조 메모
Purified from cultures of Clostridium tetani by a modification of the method of Robinson, et al.
재구성
Each vial, when reconstituted with 100 μL of sterile purified water, contains 25 μg of tetanus toxin in 20 mM HEPES, pH 7.4 with 1.25% lactose.
분석 메모
Two bands by SDS-PAGE under reducing conditions (100 kDa heavy chain and 50 kDa light chain).
신호어
Danger
유해 및 위험 성명서
Hazard Classifications
Acute Tox. 1 Oral - Acute Tox. 2 Inhalation - STOT SE 1
표적 기관
Central nervous system
Storage Class Code
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
MODELS vert The Tetanus Toxin Model of Temporal Lobe Epilepsy
Endocrine regulations, 804-807 (2009)
Felix Horns et al.
Cell reports, 30(3), 905-913 (2020-01-23)
Antibody memory protects humans from many diseases. Protective antibody memory responses require activation of transcriptional programs, cell proliferation, and production of antigen-specific antibodies, but how these aspects of the response are coordinated is poorly understood. We profile the molecular and
Secretory carrier membrane protein 5 is an autophagy inhibitor that promotes the secretion of alpha-synuclein via exosome
Yang Y, et al.
PLoS ONE, 12(7), e0180892-e0180892 (2017)
Tetanus
Hunter's Tropical Medicine and Emerging Infectious Disease, 508-510 (2013)
Rodolfo M Iglesias et al.
Neurochemical research, 37(6), 1355-1363 (2012-02-24)
Pannexin1 (Panx1), a protein related to the gap junction proteins of invertebrates, forms nonjunctional channels that open upon depolarization and in response to mechanical stretch and purinergic receptor stimulation. Importantly, ATP can be released through Panx1 channels, providing a possible
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