T0376

Thymine

≥99%

• 동의어(들): 2,4-Dihydroxy-5-methylpyrimidine, 5-Methyluracil
• 실험식(Hill 표기법): C₅H₆N₂O₂
• CAS Number: 65-71-4
• Molecular Weight: 126.11
• Beilstein: 117880
• EC Number: 200-616-1
• MDL number: MFCD00006026
• UNSPSC 코드: 41106305
• PubChem Substance ID: 24899883
• NACRES: NA.51

속성

• 생물학적 소스: synthetic (organic)
• Quality Level: 200
• 분석: ≥99%
• 양식: powder
• mp: ~320 °C (dec.) (lit.)
• SMILES string: CC1=CNC(=O)NC1=O
• InChI: 1S/C5H6N2O2/c1-3-2-6-5(9)7-4(3)8/h2H,1H3,(H2,6,7,8,9)
• InChI key: RWQNBRDOKXIBIV-UHFFFAOYSA-N
• 유전자 정보: mouse ... Tymp(72962)

설명

일반 설명

Thymine is one of the four nucleobases, along with adenine, guanine and cytosine found in deoxyribonucleic acids (DNA).[1]

애플리케이션

Thymine has been used as a standard nitrogenous base in high-performance liquid chromatography-ultraviolet (HPLC-UV) for the quantification of bone DNA samples,[2] Raman scattering experiments[3]. It has also been used as supplement in C2C12 myoblast cells.[4] Thymine may be used to study chemical processes that affect DNA structure, such a radiation induced radical production leading to base cross-linking reactions and derivitizations. It may be used to study the parameters of hydrogen bonding kinetics and energies with other nucleobases such as adenine.Thymine is used to develop sensitive heavy metal (mercury) detectors based on coordination chemistry and nanoparticle structures.

생화학적/생리학적 작용

Thymine used in studying DNA structure byirradtaion methods leading to cross-linking reactions and derivitizations.[5] Thymine dimers are indicative of DNA damage.[6] Thymine is used with metal (mercury) to form thymine−HgII−thymine (T−HgII−T) duplexes.[7] Thymine starvation in bacteria leads to halt in DNA synthesis and is referred as thymine-less death.[8]

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)