SRP6517

Alpha 2HS Glycoprotein from human plasma

≥90% (SDS-PAGE)

• 동의어(들): Alpha-2-Z-globulin, Ba-alpha-2-glycoprotein, Fetuin-A
• UNSPSC 코드: 12352202
• NACRES: NA.32

속성

• 생물학적 소스: human
• 분석: ≥90% (SDS-PAGE)
• 양식: lyophilized
• 분자량: 49 kDa
• 포장: pkg of 1 mg
• UniProt 수납 번호: P02765
• 배송 상태: wet ice
• 저장 온도: −20°C
• 유전자 정보: human ... AHSG(197)

설명

일반 설명

AHSG (α2-HS glycoprotein), or fetuin-A, is a predominant serum glycoprotein with a molecular weight of 64kDa, and is produced and secreted primarily by hepatic cells. It is highly present in the extracellular matrix (ECM) of the bone.[1][2]

생화학적/생리학적 작용

AHSG (α2-HS glycoprotein) is a multifunctional protein, and acts as an inhibitor of insulin receptor tyrosine kinase. It is involved in insulin resistance by promoting adipose tissue inflammation by functioning as a ligand for Toll-like receptor 4. Therefore, it is linked to the type 2 diabetes. This protein plays a crucial role in the prevention of extracellular calcification. This protein is a candidate plasma biomarker for early hypopharyngeal squamous cell carcinoma (HSCC) diagnosis. It is also a negative acute-phase protein, and its serum levels reduce drastically following surgeries, trauma, burns, and severe inflammation.[1][2] Studies in Chinese populations show the serum levels of this protein is linked with fatty liver index (FLI), alanine aminotransferance (ALT), and aspartate aminotransferance (AST), which are early indicators of nonalcoholic fatty liver disease (NAFLD).[3]

물리적 형태

Lyophilized from 20 mM Tris-HCl, pH 7.5, with 2 mM EDTA.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable