SRP6371

Aldose Reductase human

recombinant, expressed in E. coli, ≥95% (SDS-PAGE)

• 동의어(들): ADR, AKR1B1, ALDR1, ALR2, AR, Aldo-keto reductase family1, member B1
• UNSPSC 코드: 12352204
• NACRES: NA.32

속성

• 생물학적 소스: human
• 재조합: expressed in E. coli
• 분석: ≥95% (SDS-PAGE)
• 형태: liquid
• 분자량: 35.8 kDa (316 aa, 1-316 aa)
• 포장: pkg of 100 μg
• 농도: 1 mg/mL
• UniProt 수납 번호: P15121
• 배송 상태: dry ice
• 저장 온도: −70°C
• 유전자 정보: human ... AKR1B1(231)

설명

일반 설명

Aldose reductase (AKR1B1) is a member of the aldo-keto reductase (AKR) superfamily. Recombinant aldose reductase (AKR1B) protein was expressed in Escherichia coli and purified by using conventional chromatography techniques. It is expressed in eye and kidney, but predominant in placenta. The AKR1B1 gene is mapped to human chromosome 7q33.

생화학적/생리학적 작용

Aldose reductase (AKR1B1) catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. This protein is implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. AKR1B1 is also involved in cytokine-mediated generation of prostaglandin F2α (PGF2α) in preadipocytes. It participates in diabetes-associated mitochondrial disorder and damage via the activation of p53. AKR1B1 is associated with drug resistance mechanism in cancer-derived cell lines. It is also known to mediate cellular processes linked to carcinogenesis such as EMT (epithelial–mesenchymal transition), inflammation and angiogenesis. Aldose reductase mediates glucose metabolism in placenta and osmotic control in eye and kidney.

물리적 형태

1 mg/mL in 20 mM Tris-HCl buffer (pH 8.0) containing 1 mM DTT and 10% glycerol.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H319
• 예방조치 성명서: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Eye Irrit. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable