The protein concentration is measured by its absorbance at A280, utilizing an extinction coefficient of 0.703 for a 0.1% solution at a 1 cm path length.
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추천 제품
생물학적 소스
human
분석
≥95% (SDS-PAGE)
양식
lyophilized
효능
≥5.0 I.U. per mg
분자량
52 kDa
포장
pkg of 1 mg
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
유전자 정보
human ... Serpin A1(5265)
일반 설명
Our Alpha 1 Antitrypsin is a human plasma protein.It is shown to be HBsAg, HCV, HBc free and also negative for anti HIV1 and HIV2 according to FDA approved tests.
The gene AAT (α 1 antitrypsin) is mapped to human chromosome 14q32.1.[1] AAT is an acute-phase plasma protein.[2] It is a water soluble glycoprotein. AAT is mainly secreted by hepatocytes, macrophages, and some cancer cells.[3] AAT is also referred to as Serpin A1.
The gene AAT (α 1 antitrypsin) is mapped to human chromosome 14q32.1.[1] AAT is an acute-phase plasma protein.[2] It is a water soluble glycoprotein. AAT is mainly secreted by hepatocytes, macrophages, and some cancer cells.[3] AAT is also referred to as Serpin A1.
애플리케이션
AAT (α 1 antitrypsin) from human plasma has been used as a standard to check the presence of AAT in benign and malignant lymphoreticular cells and tissues.[4]
생화학적/생리학적 작용
AAT (α 1 antitrypsin) functions as a serine protease inhibitor with targets like elastase, plasmin, collagenase, thrombin, leucocyte proteases, trypsin, chymotrypsin and plasminogen activator.[3][5] Clinically, its deficiency is associated with two major diseases: pulmonary emphysema and early onset/juvenile hepatic cirrhosis.[3][6] It is elevated in inflammatory conditions, malignancies, liver disease and pregnancy and also after surgical trauma and use of oral contraceptives.[7][8] The simultaneous quantitative determination of AAT and ceruloplasmin permits differential diagnosis of liver afflictions. Rise in AAT occurs as an acute phase response to tissue necrosis and inflammation.[9] It might work as a biomarker for cutaneous squamous cell carcinoma, hepatitis B, insulinomas, NSCLC (non-small cell lung cancer), papillary thyroid carcinoma, lung cancer and breast carcinoma.[10]
물리적 형태
Lyophilized from 30 mM Na Phosphate, pH 6.5 with 300 mM NaCl.
재구성
In water or aqueous buffer
Storage Class Code
13 - Non Combustible Solids
WGK
nwg
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
시험 성적서(COA)
Lot/Batch Number
이미 열람한 고객
Alpha 1 antitrypsin deficiency: the clinical and physiological features of pulmonary emphysema in subjects homozygous for Pi type Z. A survey by the British Thoracic Association.
Tobin MJ
British Journal of Diseases of the Chest, 77, 14-27 (1983)
Impaired hepcidin expression in alpha-1-antitrypsin deficiency associated with iron overload and progressive liver disease.
Schaefer B
Human Molecular Genetics, 24, 6254-6263 (2015)
SERPINA1 is a direct estrogen receptor target gene and a predictor of survival in breast cancer patients.
Chan HJ
Oncotarget, 6, 25815-25827 (2015)
Hepatic steatosis depresses alpha-1-antitrypsin levels in human and rat acute pancreatitis.
Wang Q
Scientific Reports, 5, doi: 10-doi: 10 (2015)
alpha 1-Antitrypsin: molecular pathology, leukocytes, and tissue damage.
Carrell RW
The Journal of Clinical Investigation, 78, 1427-1431 (1986)
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How is the amount of Alpha 2-Antiplasmin in the vial supplied (lyophilized) determined? Specifically, which assay is used to determine the amount of Alpha 2-Antiplasmin (100 ug)?
1 답변-
도움이 되었습니까?
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What is the correct molecular weight for alpha 2 antiplasmin?
1 답변-
The predicted molecular weight of human alpha-2 antiplasmin, based on its amino acid sequence, is approximately 50,500. However, when 11-14% carbohydrate content is considered, the molecular weight increases to a maximum of about 58,000. Despite this, physical measurements of the molecular weight have varied from 63,000 to 70,500.
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자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
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