SRP6087

AKR1C1 human

recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

• 동의어(들): 20-alpha HSD, Aldo-keto reductase family 1 member C1, DD1/DD2, DDH1, HBAB
• CAS Number: 1527538-64-2
• UNSPSC 코드: 12352200
• NACRES: NA.32

속성

• 생물학적 소스: human
• 재조합: expressed in E. coli
• 분석: ≥90% (SDS-PAGE)
• 양식: liquid
• 분자량: 38.9 kDa
• 포장: pkg of 100 μg
• NCBI 수납 번호: Q04828
• 배송 상태: dry ice
• 저장 온도: −70°C
• 유전자 정보: human ... AKR1C1(1645)

설명

일반 설명

AKR1C1 (aldo-keto reductase 1C1) is one of the four isoforms (AKR1C1–AKR1C4) of the phase I drug-metabolizing enzyme family called AKR1C.[1][2] This enzyme is thought to be composed of 323 amino acids, and its mRNA is expressed in brain, mammary gland tissues, liver, adrenal, prostate, uterus and testis.[3]

생화학적/생리학적 작용

AKR1C (aldo-keto reductase 1C) family of proteins is responsible for maintaining steroid homeostasis, activation of polycyclic aromatic hydrocarbons and the metabolism of prostaglandin. These enzymes function as NAD(P)(H)-dependent oxidoreductases and are responsible for the production of alcohol by catalyzing the reduction of aldehydes and ketones. Studies show that up-regulation of AKR1C1 is linked with resistance to anti-cancer therapeutics such as, adriamycin, daunorubicin and cisplatin.[1] In human endometrial tissues, this protein is responsible for the conversion of progesterone to a biologically inactive metabolite. Studies in cultured endometrial stromal cells show that the mRNA expression level of AKR1C1 is inversely dependent on the level of progesterone, thus suggesting that progesterone controls its own local concentration through AKR1C1 enzyme in endometrial stromal cells at peri-implantation periods.[4]

물리적 형태

0.5 mg/mL solution in 20 mM Tris-HCl buffer (pH 8.0) containing 1 mM DTT and 20% glycerol.

제조 메모

Centrifuge the vial prior to opening.

기타 정보

MGSSHHHHHH SSGLVPRGSH MDSKYQCVKL NDGHFMPVLG FGTYAPAEVP KSKALEATKL AIEAGFRHID SAHLYNNEEQ VGLAIRSKIA DGSVKREDIF YTSKLWCNSH RPELVRPALE RSLKNLQLDY VDLYLIHFPV SVKPGEEVIP KDENGKILFD TVDLCATWEA VEKCKDAGLA KSIGVSNFNR RQLEMILNKP GLKYKPVCNQ VECHPYFNQR KLLDFCKSKD IVLVAYSALG SHREEPWVDP NSPVLLEDPV LCALAKKHKR TPALIALRYQ LQRGVVVLAK SYNEQRIRQN VQVFEFQLTS EEMKAIDGLN RNVRYLTLDI FAGPPNYPFS DEY

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H319
• 예방조치 성명서: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Eye Irrit. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable