추천 제품
생물학적 소스
human
재조합
expressed in E. coli
분석
≥95% (SDS-PAGE)
형태
liquid
분자량
42.9 kDa
포장
pkg of 100 μg
NCBI 수납 번호
UniProt 수납 번호
배송 상태
dry ice
저장 온도
−70°C
유전자 정보
human ... PPID(5481)
일반 설명
Cyclophilin D is a member of peptidyl-propyl cis-trans isomerase (PPIase) family. It is a mitochondrial matrix protein and a component of the mitochondrial permeability transition pore (MPTP).
애플리케이션
Human cyclophilin D has been used to study the effects of muscle denervation on the opening of the permeability transition pore and on the expression of cyclophilin D in rats.
생화학적/생리학적 작용
Cyclophilin D catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerates the folding of proteins and thus their formation. It plays a decisive role in mitochondrial permeability transition. The protein can bind to the immunosuppressant cyclosporine A and its overexpression suppresses the apoptosis in cancer cells.
물리적 형태
1 mg/mL solution in PBS (pH 7.4) containing 10% glycerol.
제조 메모
Centrifuge the vial prior to opening.
기타 정보
MGSSHHHHHH SSGLVPRGSH MSHPSPQAKP SNPSNPRVFF DVDIGGERVG RIVLELFADI VPKTAENFRA LCTGEKGIGH TTGKPLHFKG CPFHRIIKKF MIQGGDFSNQ NGTGGESIYG EKFEDENFHY KHDREGLLSM ANAGRNTNGS QFFITTVPTP HLDGKHVVFG QVIKGIGVAR ILENVEVKGE KPAKLCVIAE CGELKEGDDG GIFPKDGSGD SHPDFPEDAD IDLKDVDKIL LITEDLKNIG NTFFKSQNWE MAIKKYAEVL
Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Muscle denervation promotes opening of the permeability transition pore and increases the expression of cyclophilin D
Kristina Csukly
The Journal of Physiology (2006)
Giuseppe Federico Amodeo et al.
International journal of molecular sciences, 22(20) (2021-10-24)
The c subunit of the ATP synthase is an inner mitochondrial membrane (IMM) protein. Besides its role as the main component of the rotor of the ATP synthase, c subunit from mammalian mitochondria exhibits ion channel activity. In particular, c
Influence of cyclophilin D protein expression level on endothelial cell oxidative damage resistance.
Peng JZ
Genetics and molecular research : GMR, 14(2), 4258-4268 (2015)
Jeejabai Radhakrishnan et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(7), 2734-2748 (2015-04-04)
Cyclophilin-D (Cyp-D) is a mitochondrial matrix peptidyl-prolyl isomerase. Because cyclophilins can regulate nuclear gene expression, we examined whether Cyp-D could regulate mitochondrial gene expression. We demonstrated in HEK 293T cells that transfected Cyp-D interacts with mitochondrial transcription factors B1 and
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