SRP5350

CRKL, His tagged human

recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

• 동의어(들): crk-like protein
• CAS Number: 622897-68-1
• UNSPSC 코드: 12352204
• NACRES: NA.32

속성

• 생물학적 소스: human
• 재조합: expressed in baculovirus infected Sf9 cells
• 분석: ≥70% (SDS-PAGE)
• 양식: buffered aqueous glycerol solution
• 분자량: ~39 kDa
• NCBI 수납 번호: NM_005207
• 응용 분야: cell analysis
• 배송 상태: dry ice
• 저장 온도: −70°C
• 유전자 정보: human ... CRKL(1399)

설명

일반 설명

CRKL or v-crk sarcoma virus CT10 oncogene homolog (avian)-like is a protein kinase containing SH2 and SH3 (src homology) domains that activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase which plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic. CRKL is also required for normal cellular responses to Fgf8, including survival and migration, Erk activation, and target gene expression.

물리적 형태

Supplied in 50 mM sodium phosphate, pH 7.0, 300 mM NaCl, 150 mM imidazole, 0.1 mM PMSF, 0.2 mM DTT, 25% glycerol.

제조 메모

After opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles.

안전성 정보

• 픽토그램: GHS08,GHS07
• 신호어: Danger
• 유해 및 위험 성명서: H315,H319,H360D
• 예방조치 성명서: P202 - P264 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable