SRP5346

CyclinC, GST tagged human

recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

• 동의어(들): CCNC, CycC
• UNSPSC 코드: 12352202
• NACRES: NA.32

속성

• 재조합: expressed in baculovirus infected Sf9 cells
• 분석: ≥70% (SDS-PAGE)
• 양식: buffered aqueous glycerol solution
• 분자량: ~55 kDa
• NCBI 수납 번호: NM_005190
• 배송 상태: dry ice
• 저장 온도: −70°C
• 유전자 정보: human ... CCNC(892)

설명

일반 설명

Cyclin C is a member of the cyclin family of proteins. The gene encoding it is localized on human chromosome 6q16.2.[1]

생화학적/생리학적 작용

Cyclin C interacts with the cyclin-dependent kinase 8 (CDK8)[2] and induces the phosphorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II. The mRNA levels of Cyclin C fluctuate during the cell cycle and peak at the G1 phase. Cyclin C acts as a critical regulator of the G0/G1 transition of human hematopoietic stem cells.[3] Cyclin C can also associate with CDK3 to enhance retinoblastoma phosphorylation at S807/811 during the G0/G1 transition,[4] and this phosphorylation is required for cells to exit G0 efficiently.

물리적 형태

Supplied in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.

제조 메모

After opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable