SRP5101
ZAK, active, GST tagged human
PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
동의어(들):
AZK, MLK7, MLT, MLTK, MRK, mlklak
로그인조직 및 계약 가격 보기
크기 선택
10 μG
₩824,891
₩824,891
예상 입고일2025년 5월 07일세부사항
모든 사진(2)
크기 선택
보기 변경
10 μG
₩824,891
About This Item
UNSPSC 코드:
12352202
NACRES:
NA.32
₩824,891
예상 입고일2025년 5월 07일세부사항
재조합
expressed in baculovirus infected Sf9 cells
제품 라인
PRECISIO® Kinase
분석
≥70% (SDS-PAGE)
양식
buffered aqueous glycerol solution
특이 활성도
53-71 nmol/min·mg
분자량
~82 kDa
NCBI 수납 번호
배송 상태
dry ice
저장 온도
−70°C
유전자 정보
human ... ZAK(51776)
일반 설명
ZAK is a member of the MAPKKK family of signal transduction molecules and mediates gamma radiation signaling leading to cell cycle arrest. The activity of ZAK plays a role in cell cycle checkpoint regulation as well as being involved in regulating actin organization. Expression of kinase-dead ZAK in mouse fibroblasts disrupts actin stress fibers and causes morphologic changes. ZAK can activate JNK through MKK4/MKK7 and ERK5/p38-gamma via MKK3/MKK6. Expression of ZAK increases the population of cells in the G2/M phase of the cell cycle, whereas dominant-negative ZAK attenuated the G2 arrest caused by gamma radiation.
물리적 형태
Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
제조 메모
after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles
법적 정보
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
10 - Combustible liquids
WGK
WGK 1
가장 최신 버전 중 하나를 선택하세요:
Jaw-Ji Yang
Biochemical and biophysical research communications, 297(1), 105-110 (2002-09-11)
The leucine-zipper (LZ) and sterile-alpha motif (SAM) kinase (ZAK) belongs to the MAP kinase kinase kinase (MAP3K) when upon over-expression in mammalian cells activates the JNK/SAPK pathway. The mechanisms by which ZAK activity is regulated are not well understood. Co-expression
Eleanore A Gross et al.
The Journal of biological chemistry, 277(16), 13873-13882 (2002-02-12)
Mitogen-activated protein (MAP) kinase pathways are three-kinase modules that mediate diverse cellular processes and have been highly conserved among eukaryotes. By using a functional complementation screen in yeast, we have identified a human MAP kinase kinase kinase (MAPKKK) that shares
활성 필터
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