추천 제품
생물학적 소스
human
재조합
expressed in E. coli
분석
≥98% (HPLC)
≥98% (SDS-PAGE)
형태
lyophilized
효능
≤0.5 ng/mL ED50
분자량
12.9 kDa
포장
pkg of 10 μg
기술
cell culture | mammalian: suitable
불순물
<0.1 EU/μg endotoxin, tested
색상
white to off-white
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
유전자 정보
human ... IL15(3600)
일반 설명
Interleukin-15 (IL-15) is an immunomodulating cytokine. The gene encoding it is localized on chromosome 4q31. Human IL-15 is biologically active on mouse cells as measured by the dose-dependent stimulation of the proliferation of mouse CTLL cells. Recombinant human IL-15 is a 12.9kDa protein consisting of 115 amino acid residues.
생화학적/생리학적 작용
Interleukin-15 (IL-15) stimulates the proliferation of T lymphocytes and shares many biological properties with IL-2. It exerts its biological activities primarily on T cells. It is also essential in the development, survival and activation of NK cells. On binding to its receptor, IL-15 is indirectly involved in activating proto-oncogenes. Increased expression of IL-15 has been implicated with rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis and diseases affiliated with retroviruses like human immunodeficiency virus (HIV) and human T-lymphotropic virus-1 (HTLV-I).
서열
MNWVNVISDL KKIEDLIQSM HIDATLYTES DVHPSCKVTA MKCFLLELQV ISLESGDASI HDTVENLIIL ANNSLSSNGN VTESGCKECE ELEEKNIKEF LQSFVHIVQM FINTS
물리적 형태
Lyophilized from 10 mM Sodium Phosphate, pH 8.5.
재구성
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a stabilizer (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
이미 열람한 고객
McKenzie, A.N.J., et al.
Cytokine Reference, 203-211 (2001)
Mario Bunse et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 22(11), 1983-1991 (2014-07-23)
Genetically modified T cells that express a transduced T cell receptor (TCR) α/β heterodimer in addition to their endogenous TCR are used in clinical studies to treat cancer. These cells express two TCR-α and two TCR-β chains that do not
K H Grabstein et al.
Science (New York, N.Y.), 264(5161), 965-968 (1994-05-13)
A cytokine was identified that stimulated the proliferation of T lymphocytes, and a complementary DNA clone encoding this new T cell growth factor was isolated. The cytokine, designated interleukin-15 (IL-15), is produced by a wide variety of cells and tissues
Gerharda H Boerman et al.
Cancer immunology, immunotherapy : CII, 64(5), 573-583 (2015-04-10)
Children with advanced stages (relapsed/refractory and stage IV) of rhabdomyosarcoma (RMS) have a poor prognosis despite intensive chemotherapy and autologous stem cell rescue, with 5-year survival rates ranging from 5 to 35 %. Development of new, additional treatment modalities is
Chromosomal assignment and genomic structure of Il15.
Anderson DM
Genomics, 25(3), 701-706 (1995)
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