SRP3064

IGF-Binding Protein 4 human

recombinant, expressed in (BTI-Tn-5B1-4) High-5 Insect Cells, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture

• 동의어(들): HT29-IGF-BP, IBP-4, colon cancer cell growth inhibitor
• UNSPSC 코드: 51111800
• NACRES: NA.32

속성

• 생물학적 소스: human
• 재조합: expressed in (BTI-Tn-5B1-4) High-5 Insect Cells
• 분석: ≥98% (HPLC); ≥98% (SDS-PAGE)
• 양식: lyophilized
• 분자량: 25.8 kDa
• 포장: pkg of 20 μg
• 기술: cell culture | mammalian: suitable
• 불순물: <0.1 EU/μg endotoxin, tested
• 색상: white to off-white
• UniProt 수납 번호: P22692
• 배송 상태: wet ice
• 저장 온도: −20°C
• 유전자 정보: human ... IGFBP4(3487)

설명

일반 설명

The gene IGFBP4 (insulin-like growth factor-binding protein 4) is mapped to human chromosome 17q21.[1] It belongs to the IGFBP family of proteins. The protein has a IGF (insulin-like growth factor)-binding site and a thyroglobulin type-1 domain. IGFBPs are mainly required to regulate IGFs activities.[2] IGFBP4 can be cleaved by PAPP-A (pregnancy-associated plasma protein-A) in IGF-dependent mechanism.[3]
Recombinant human IGF-BP4 is a 25.7kDa protein consisting of 237 amino acid residues including the IGF-BP domain and thyroglobulin type-I domain.

애플리케이션

IGF-Binding Protein 4 human has been used to check the dependency of FSH (follicle-stimulating hormone) action in human Cumulus granulosa cells on IGF-2 (insulin-like growth factor 2).[4]

생화학적/생리학적 작용

IGFBP4 (insulin-like growth factor-binding protein 4) suppresses cell proliferation and DNA synthesis and induces cell death.[5] IGFBP4 participates in adipose tissue expandability and interacts with IGF1 (insulin-like growth factor 1). Interaction with IGF1 disrupts mitogenic signaling.[6] IGFBP4 is suggested as a serum biomarker of Lupus Nephritis and is associated with the chronicity of renal pathology in patients.[7] IGFBP4 is also linked with cardiovascular death in type 1 diabetes patients in the absence/presence of nephropathy.[8] It is also linked with the progression of tumors.[2]

서열

DEAIHCPPCS EEKLARCRPP VGCEELVREP GCGCCATCAL GLGMPCGVYT PRCGSGLRCY PPRGVEKPLH TLMHGQGVCM ELAEIEAIQE SLQPSDKDEG DHPNNSFSPC SAHDRRCLQK HFAKIRDRST SGGKMKVNGA PREDARPVPQ GSCQSELHRA LERLAASQSR THEDLYIIPI PNCDRNGNFH PKQCHPALDG QRGKCWCVDR KTGVKLPGGL EPKGELDCHQ LADSFRE

물리적 형태

Lyophilized from 1x PBS, pH 7.2.

재구성

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable