추천 제품
일반 설명
BMP6 (bone morphogenetic protein 6) is one of the BMPs which are secreted signaling proteins belonging to the transforming growth factor-β (TGF-β) superfamily. This gene is localized to human chromosome 6p24.1.
Recombinant human BMP-6 is a 26.2kDa homodimeric glycoprotein consisting of two 117 amino acid subunits, which correspond to amino acid residues 397 to 513 of the full-length BMP-6 precursor.
Recombinant human BMP-6 is a 26.2kDa homodimeric glycoprotein consisting of two 117 amino acid subunits, which correspond to amino acid residues 397 to 513 of the full-length BMP-6 precursor.
생화학적/생리학적 작용
BMPs (bone morphogenetic proteins) were initially identified from demineralized bone extracts capable of stimulating endochondral osteogenesis at extraskeletal sites in vivo. BMP6 is thought to be involved in early embryogenesis. In hepatocellular carcinoma (HCC) the expression of this protein is suppressed due to hypermethylation, and this is linked with poor patient outcomes. This protein is also down-regulated due to CpG island methylation in CRC (colorectal carcinoma), although it is not yet been found to be linked with tumor progression or prognosis. BMP6 is involved in chondrocyte differentiation, and in fetal kidney and urinary system development. It is thought to be involved in ovulation, where it elevates the accumulation of neutrophils in ovulatory follicles and reduces the influence of protease inhibitors.
서열
VSSASDYNSS ELKTACRKHE LYVSFQDLGW QDWIIAPKGY AANYCDGECS FPLNAHMNAT NHAIVQTLVH LMNPEYVPKP CCAPTKLNAI SVLYFDDNSN VILKKYRNMV VRACGCH
물리적 형태
Lyophilized from 10 mM Tris, pH 9.0.
재구성
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
이미 열람한 고객
Hypermethylation leads to bone morphogenetic protein 6 downregulation in hepatocellular carcinoma.
He Y et al
PLoS ONE, 9(1), e87994-e87994 (2014)
Genetic dissection and prognostic modeling of overt stroke in sickle cell anemia.
Sebastiani P et al
Nature Genetics, 37(4), 435-440 (2005)
Expression of BMP6 is associated with its methylation status in colorectal cancer tissue but lacks prognostic significance.
Sangplod P et al
Asian Pacific Journal of Cancer Prevention, 15(17), 7091-7095 (2014)
The role of bone morphogenetic protein 6 in accumulation and regulation of neutrophils in the human ovary.
Akiyama I et al
Reproductive Sciences, 21(6), 772-777 (2014)
S M Lens et al.
Seminars in immunology, 10(6), 491-499 (1998-11-25)
In contrast to the expression of other TNFR/TNF family members, expression of CD27 and its ligand CD70 is predominantly confined to lymphocytes. High expression levels of CD27 appear to be dependent on proper ligation of antigen receptors, whereas for the
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
고객지원팀으로 연락바랍니다.