SRP2148

EF1α, GST tagged human

recombinant, expressed in E. coli, ≥85% (SDS-PAGE)

• 동의어(들): CCS3, EE1A1, EEF-1, EEF1A, EF-Tu, EF1A, FLJ25721, LENG7, PTI1, eEF1A-1
• UNSPSC 코드: 12352200
• NACRES: NA.26

속성

• 생물학적 소스: human
• 재조합: expressed in E. coli
• 분석: ≥85% (SDS-PAGE)
• 양식: frozen liquid
• 분자량: ~77.3 kDa
• 포장: pkg of 10 μg
• 농도: 350 μg/mL
• 색상: colorless to clear
• NCBI 수납 번호: NM_001402
• UniProt 수납 번호: P68104
• 배송 상태: dry ice
• 저장 온도: −70°C
• 유전자 정보: human ... EEF1A1(1915)

설명

생화학적/생리학적 작용

The alpha subunit of elongation factor-1 (EEF1A) is involved in the binding of aminoacyl-tRNAs to 80S ribosomes. During the process, GTP is hydrolyzed into GDP. To perform this function, EEF1A has domains that bind guanine nucleotides, 80S ribosomes, and aminoacyl-tRNAs. Also, EEF1A interacts with the beta subunit of EEF1 to exchange bound GDP for GTP. Multimolecular complexes involving the eukaryotic elongation factor 1A (eEF1A) have been suggested to play an important role in the channeling (vectorial transfer) of tRNA during protein synthesis HIV-1 matrix protein (MA) was found to interact with elongation factor 1-α (EF1α), an essential component of the translation machinery that delivers aminoacyl-tRNA to ribosomes. The interaction between MA and EF1α impairs translation in vitro, a result consistent with a previously proposed model in which inhibition of translation by the accumulation of Gag serves to release viral RNA from polysomes, permitting the RNA to be packaged into nascent virions. It has been identified that the translation elongation factor, eEF1A, and its guanine nucleotide exchange factor, eEF1Bβ, as translationally controlled tumor protein (TCTP)-interacting partners.

물리적 형태

Clear and colorless frozen liquid solution

제조 메모

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable