SML3907
CNS-11g
≥98% (HPLC)
동의어(들):
2-(4-benzyl-1-oxo-2(1H)-phthalazinyl)-N-(2,6-dimethylphenyl)acetamide, N-(2,6-Dimethylphenyl)-1-oxo-4-(phenylmethyl)-2(1H)-phthalazineacetamide
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모든 사진(2)
About This Item
실험식(Hill 표기법):
C25H23N3O2
CAS Number:
Molecular Weight:
397.47
MDL number:
UNSPSC 코드:
12352200
NACRES:
NA.77
추천 제품
Quality Level
분석
≥98% (HPLC)
양식
powder
색상
white to beige
solubility
DMSO: 2 mg/mL, clear (Warmed)
저장 온도
2-8°C
생화학적/생리학적 작용
Brain tissue penetrant alpha-synuclein ligand that potently disaggregate alpha-synuclein fibrils in vitro and in vivo models.
CNS-11g is brain tissue penetrant alpha-synuclein ligand that potently disaggregate alpha-synuclein fibrils in vitro and in vivo models. CNS-11g inhibits intracellular seeding of a-synuclein fibrils in biosensor cells-HEK293T cells and mitigate a-synuclein cytotoxicity in Neuro-2a (N2a) neuronal cells. C-11g reduces number of a-synuclein aggregates in C. elegans model.
CNS-11g is brain tissue penetrant alpha-synuclein ligand that potently disaggregate alpha-synuclein fibrils in vitro and in vivo models. CNS-11g inhibits intracellular seeding of a-synuclein fibrils in biosensor cells-HEK293T cells and mitigate a-synuclein cytotoxicity in Neuro-2a (N2a) neuronal cells. C-11g reduces number of a-synuclein aggregates in C. elegans model.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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시험 성적서(COA)
Lot/Batch Number
Small molecules disaggregate alpha-synuclein and prevent seeding from patient brain-derived fibrils.
Kevin A Murray et al.
Proceedings of the National Academy of Sciences of the United States of America, 120(7), e2217835120-e2217835120 (2023-02-10)
The amyloid aggregation of alpha-synuclein within the brain is associated with the pathogenesis of Parkinson's disease (PD) and other related synucleinopathies, including multiple system atrophy (MSA). Alpha-synuclein aggregates are a major therapeutic target for treatment of these diseases. We identify
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