Quality Level
분석
≥98% (HPLC)
양식
powder
색상
white to beige
solubility
DMSO: 2 mg/mL, clear (Warmed)
저장 온도
2-8°C
SMILES string
O=C1C2=C(C(C3=C4C=CC=C3)=NN1CC(NC5=C(C)C=C(C)C=C5C)=O)C4=CC=C2
InChI key
MVMNMAWCMNMLEC-UHFFFAOYSA-N
생화학적/생리학적 작용
Brain tissue penetrant alpha-synuclein ligand that potently disaggregate alpha-synuclein fibrils in vitro and in vivo models.
CNS-11 is brain tissue penetrant alpha-synuclein ligand that potently disaggregate alpha-synuclein fibrils in vitro and in vivo models. CNS-11 inhibits intracellular seeding of a-synuclein fibrils in biosensor cells—HEK293T cells. C-11 reduces number of a-synuclein aggregates in C. elegans model.
CNS-11 is brain tissue penetrant alpha-synuclein ligand that potently disaggregate alpha-synuclein fibrils in vitro and in vivo models. CNS-11 inhibits intracellular seeding of a-synuclein fibrils in biosensor cells—HEK293T cells. C-11 reduces number of a-synuclein aggregates in C. elegans model.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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시험 성적서(COA)
Lot/Batch Number
Structure-based discovery of small molecules that disaggregate Alzheimer's disease tissue derived tau fibrils in vitro
Nature Communications, 13(1), 5451-5451 (2022)
Small molecules disaggregate alpha-synuclein and prevent seeding from patient brain-derived fibrils.
Kevin A Murray et al.
Proceedings of the National Academy of Sciences of the United States of America, 120(7), e2217835120-e2217835120 (2023-02-10)
The amyloid aggregation of alpha-synuclein within the brain is associated with the pathogenesis of Parkinson's disease (PD) and other related synucleinopathies, including multiple system atrophy (MSA). Alpha-synuclein aggregates are a major therapeutic target for treatment of these diseases. We identify
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