SML3574
5-Ph-IAA
≥97% (HPLC)
동의어(들):
2-(5-Phenyl-1H-indol-3-yl)acetic acid, 5-Phenyl-1H-indole-3-acetic acid, 5-Phenyl-indole-3-acetic acid
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모든 사진(1)
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5 MG
₩123,424
25 MG
₩498,365
About This Item
실험식(Hill 표기법):
C16H13NO2
CAS Number:
Molecular Weight:
251.28
MDL number:
UNSPSC 코드:
12352200
NACRES:
NA.21
추천 제품
Quality Level
분석
≥97% (HPLC)
양식
powder
색상
white to beige
solubility
DMSO: 2 mg/mL, clear
저장 온도
2-8°C
SMILES string
O=C(CC1=CNC2=CC=C(C3=CC=CC=C3)C=C21)O
InChI key
ACCCWYHBDGKDKN-UHFFFAOYSA-N
생화학적/생리학적 작용
5-Ph-IAA is a bumped auxin-inducible degron (AID) ligand that induces Skp1-Cul1-F-box (SCF) E3 ligase complex-mediated ubiquitinaton of Arabidopsis IAA17-derived mini-AID (mAID) degron-fused target proteins in cells expressing a hole-modified Oryza sativa TIR1 (OsTIR1) mutant (F74G or F74A). Unlike the traditional AID system, 5-Ph-IAA-based AID2 method shows no detectable leaky degradation, requires a 670-times lower ligand concentration, and achieves quicker degradation in cultures (0.2-5 μM) and in vivo (1-10 mg/kg via daily i.p. to mice xenografted with HCT116 CMV-OsTIR1(F74G) cells expressing mAID-tagged BRD4 or TOP2A).
Bumped AID2 system ligand that induces degradation of IAA17-derived mini-AID (mAID) degron-fused target proteins in cultures and in vivo.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
시험 성적서(COA)
Lot/Batch Number
SIN-Like Pathway Kinases Regulate the End of Mitosis in the Methylotrophic Yeast Ogataea polymorpha
Cells, 11(9), 1519-1519 (2022)
The auxin-inducible degron 2 (AID2) system enables controlled protein knockdown during embryogenesis and development in Caenorhabditis elegans
Genetics, 220(2), iyab218-iyab218 (2022)
An engineered, orthogonal auxin analog/AtTIR1(F79G) pairing improves both specificity and efficacy of the auxin degradation system in Caenorhabditis elegans
Genetics, 220(2), iyab174-iyab174 (2022)
Yuichiro Saito et al.
Current protocols, 1(8), e219-e219 (2021-08-10)
Targeted protein depletion using a conditional degron is a powerful method to probe the role of proteins in living cells because of the speed with which depletion can be induced and its reversibility. The auxin-inducible degron (AID) is one of
The enteric nervous system of the C. elegans pharynx is specified by the Sine oculis-like homeobox gene ceh-34
eLife, 11, e76003-e76003 (2022)
활성 필터
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
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