SML3416
Hinokiflavone
≥97% (HPLC)
동의어(들):
4′,5,5′′,7,7′′-Pentahydroxy-4′′′,6-oxydi-flavone (8CI), 6-[4-(5,7-Dihydroxy-4-oxo-4H-1-benzopyran-2-yl)phenoxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
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5 MG
₩148,089
25 MG
₩595,805
About This Item
실험식(Hill 표기법):
C30H18O10
CAS Number:
Molecular Weight:
538.46
MDL number:
UNSPSC 코드:
12352200
NACRES:
NA.77
Quality Level
분석
≥97% (HPLC)
양식
powder
저장 조건
desiccated
색상
white to beige
solubility
DMSO: 2 mg/mL, clear
저장 온도
-10 to -25°C
SMILES string
[o]1c2c([c](cc1c6ccc(cc6)O)=O)c(c(c(c2)O)Oc3ccc(cc3)c4[o]c5c([c](c4)=O)c(cc(c5)O)O)O
InChI
1S/C30H18O10/c31-16-5-1-14(2-6-16)24-12-21(35)28-26(40-24)13-22(36)30(29(28)37)38-18-7-3-15(4-8-18)23-11-20(34)27-19(33)9-17(32)10-25(27)39-23/h1-13,31-33,36-37H
InChI key
WTDHMFBJQJSTMH-UHFFFAOYSA-N
생화학적/생리학적 작용
Hinokiflavone is a plant biflavone that exhibit potent anticancer, hepatoprotective, antibacterial, antiviral, and anti-inflammatory activities. Hinokiflavone induces apoptosis and cell cycle arrest, and blocks migration and invasion of melanoma cells. It is a potent inhibitor of dengue 2 virus RNA-dependent RNA polymerase (DV-NS5 RdRp). Hinokiflavone is a modulator of pre-mRNA splicing in cells. It increases SUMOylation of a subset of spliceosome proteins by inhibiting SENP1 protease activity. It induces apoptosis in esophageal squamous cell carcinoma (ESCC) through regulation of PI3K/AKT/mTOR pathway.
Modulator of pre-mRNA splicing in cells; potent inhibitor of dengue 2 virus RNA-dependent RNA polymerase (DV-NS5 RdRp)
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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시험 성적서(COA)
Lot/Batch Number
Andrea Pawellek et al.
eLife, 6 (2017-09-09)
We have identified the plant biflavonoid hinokiflavone as an inhibitor of splicing in vitro and modulator of alternative splicing in cells. Chemical synthesis confirms hinokiflavone is the active molecule. Hinokiflavone inhibits splicing in vitro by blocking spliceosome assembly, preventing formation
Paul Coulerie et al.
Planta medica, 78(7), 672-677 (2012-03-14)
In order to find new molecules for antiviral drug design, we screened 102 ethyl acetate extracts from New-Caledonian flora for antiviral activity against the dengue 2 virus RNA-dependant RNA polymerase (DV-NS5 RdRp). The leaf extract of Dacrydium balansae, which strongly
Shuping Yang et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 103, 101-110 (2018-04-11)
Melanoma, the highest degree of malignancy, is one of the most common skin tumors. However, there is no effective strategy to treat melanoma in current clinical practice. Therefore, it is urgent to find an efficient drug to overcome melanoma. Here
활성 필터
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
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