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Merck
모든 사진(1)

주요 문서

SML3384

Sigma-Aldrich

Cyclovirobuxine D

≥90% (HPLC)

동의어(들):

(3α,5α,16α,20S)-4,4,14-Trimethyl-3,20-bis(methylamino)-9,19-cyclopregnan-16-ol, (3β,5α,16α,20S)-4,4,14-trimethyl-3,20-bis(methylamino)-9,19-cyclopregnan-16-ol, Bebuxine, CVB-D

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About This Item

실험식(Hill 표기법):
C26H46N2O
CAS Number:
Molecular Weight:
402.66
MDL number:
UNSPSC 코드:
51111800
NACRES:
NA.77

Quality Level

분석

≥90% (HPLC)

형태

powder

색상

white to beige

solubility

0.1 M HCl: 2 mg/mL, clear

저장 온도

-10 to -25°C

SMILES string

C[C@H](NC)[C@@]1([H])[C@H](O)C[C@@]2(C)[C@]3([H])CC[C@@]4([H])C(C)(C)[C@@H](NC)CC[C@]4(C5)[C@]35CC[C@@]21C

InChI

1S/C26H46N2O/c1-16(27-6)21-17(29)14-24(5)19-9-8-18-22(2,3)20(28-7)10-11-25(18)15-26(19,25)13-12-23(21,24)4/h16-21,27-29H,8-15H2,1-7H3/t16-,17+,18-,19-,20-,21-,23+,24-,25+,26-/m0/s1

InChI key

GMNAPBAUIVITMI-ABNIRSKTSA-N

생화학적/생리학적 작용

Cyclovirobuxine D is a steroidal alkaloid component extracted from the root of medical plant Buxus microphylla that exhibits beneficial effect on heart failure, arrhythmias, myocardial ischemia and other cardiovascular diseases. Apparently it increases the release and uptake of Ca(2+) in systolic and diastolic periods. Cyclovirobuxine D induces mitochondria-mediated apoptosis in numerous cancer cells including breast and gastric cancer cells. It induces autophagy-associated cell death via the Akt/mTOR pathway in human breast cancer cells.

픽토그램

Skull and crossbones

신호어

Danger

유해 및 위험 성명서

Hazard Classifications

Acute Tox. 3 Oral

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

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문서 라이브러리 방문

Hanmei Wei et al.
Journal of nanoscience and nanotechnology, 18(8), 5274-5282 (2018-02-21)
The blood-brain barrier (BBB) restricts the delivery of most drugs to the brain. In our previous study, the feasibility of cyclovirobuxine D delivery to the brain by a non-invasive nasal route was evaluated. In this study, a suitable drug delivery
Bin Yu et al.
Fitoterapia, 83(8), 1653-1665 (2012-10-02)
Our previous studies have shown that cyclovirobuxine D (CVB-D) ameliorated the cardiac function in heart failure rats. Considering the relationship between cardiac function and [Ca(2+)]i, and the role of calcium cycling on regulating [Ca(2+)]i, the present study was designed to
Jie Wu et al.
Molecules (Basel, Switzerland), 20(11), 20659-20668 (2015-11-28)
Gastric cancer is one of the most common malignant cancers, with high death rates, poor prognosis and limited treatment methods. Cyclovirobuxine D (CVB-D) is the main active component of the traditional Chinese medicine Buxus microphylla. In the present study, we

자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..

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