추천 제품
Quality Level
분석
≥90% (HPLC)
형태
powder
색상
white to beige
solubility
0.1 M HCl: 2 mg/mL, clear
저장 온도
-10 to -25°C
SMILES string
C[C@H](NC)[C@@]1([H])[C@H](O)C[C@@]2(C)[C@]3([H])CC[C@@]4([H])C(C)(C)[C@@H](NC)CC[C@]4(C5)[C@]35CC[C@@]21C
InChI
1S/C26H46N2O/c1-16(27-6)21-17(29)14-24(5)19-9-8-18-22(2,3)20(28-7)10-11-25(18)15-26(19,25)13-12-23(21,24)4/h16-21,27-29H,8-15H2,1-7H3/t16-,17+,18-,19-,20-,21-,23+,24-,25+,26-/m0/s1
InChI key
GMNAPBAUIVITMI-ABNIRSKTSA-N
생화학적/생리학적 작용
Cyclovirobuxine D is a steroidal alkaloid component extracted from the root of medical plant Buxus microphylla that exhibits beneficial effect on heart failure, arrhythmias, myocardial ischemia and other cardiovascular diseases. Apparently it increases the release and uptake of Ca(2+) in systolic and diastolic periods. Cyclovirobuxine D induces mitochondria-mediated apoptosis in numerous cancer cells including breast and gastric cancer cells. It induces autophagy-associated cell death via the Akt/mTOR pathway in human breast cancer cells.
신호어
Danger
유해 및 위험 성명서
Hazard Classifications
Acute Tox. 3 Oral
Storage Class Code
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Journal of nanoscience and nanotechnology, 18(8), 5274-5282 (2018-02-21)
The blood-brain barrier (BBB) restricts the delivery of most drugs to the brain. In our previous study, the feasibility of cyclovirobuxine D delivery to the brain by a non-invasive nasal route was evaluated. In this study, a suitable drug delivery
Fitoterapia, 83(8), 1653-1665 (2012-10-02)
Our previous studies have shown that cyclovirobuxine D (CVB-D) ameliorated the cardiac function in heart failure rats. Considering the relationship between cardiac function and [Ca(2+)]i, and the role of calcium cycling on regulating [Ca(2+)]i, the present study was designed to
Molecules (Basel, Switzerland), 20(11), 20659-20668 (2015-11-28)
Gastric cancer is one of the most common malignant cancers, with high death rates, poor prognosis and limited treatment methods. Cyclovirobuxine D (CVB-D) is the main active component of the traditional Chinese medicine Buxus microphylla. In the present study, we
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
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