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Merck
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주요 문서

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SML2841

Sigma-Aldrich

Tarenflurbil

≥98% (HPLC)

동의어(들):

(R)-(−)-2-Fluoro-α-methyl-4-biphenylacetic acid, αR)-2-Fluoro-α-methyl[1,1′-biphenyl]-4-acetic acid, (-)-(R)-Flurbiprofen, (2R)-2-(3-Fluoro-4-phenylphenyl)propanoic acid, (R)-Flurbiprofen, Flurizan, R-flurbiprofen, (R)-2-Flurbiprofen, Tarenflurbil

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크기 선택

10 MG
₩47,401
50 MG
₩188,080

₩47,401

예상 입고일2025년 4월 29일세부사항

모든 사진(1)

크기 선택

보기 변경
10 MG
₩47,401
50 MG
₩188,080

About This Item

Linear Formula:
C6H5C6H3(F)CH(CH3)CO2H
CAS Number:
51543-40-9
Molecular Weight:
244.26
MDL number:
MFCD00869714
UNSPSC 코드:
12352200
NACRES:
NA.77

₩47,401

예상 입고일2025년 4월 29일세부사항

Quality Level

100

분석

≥98% (HPLC)

양식

powder

색상

white to beige

solubility

DMSO: 2 mg/mL, clear

저장 온도

2-8°C

SMILES string

C[C@@H](C(O)=O)c1ccc(c(F)c1)-c2ccccc2

InChI

1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18)/t10-/m1/s1

InChI key

SYTBZMRGLBWNTM-SNVBAGLBSA-N

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생화학적/생리학적 작용

Tarenflurbil (or R-flurbiprofen) is an R enantiomer of racemic NSAID flurbiprofen that does not inhibit either cyclooxygenase 1 (COX-1) or cyclooxygenase 2 (COX-2). Tarenflurbil potently reduces levels of beta amyloid in human cells through direct inhibition of γ-secretase.

픽토그램

Skull and crossbonesHealth hazard
GHS06,GHS08

신호어

Danger

유해 및 위험 성명서

H301 + H311,H317,H361d

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Oral - Repr. 2 - Skin Sens. 1B

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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시험 성적서(COA)

Lot/Batch Number

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문서 라이브러리 방문

T Morihara et al.
Journal of neurochemistry, 83(4), 1009-1012 (2002-11-08)
Non-steroidal anti-inflammatory drugs (NSAIDs) have been associated with reduced risk for Alzheimer's disease (AD) and selected NSAIDs racemates suppress beta-amyloid (Abeta) accumulation in vivo and Abeta42 production in vitro. Clinical use of NSAIDs for preventing or treating AD has been
Jason L Eriksen et al.
The Journal of clinical investigation, 112(3), 440-449 (2003-08-05)
Epidemiologic studies demonstrate that long-term use of NSAIDs is associated with a reduced risk for the development of Alzheimer disease (AD). In this study, 20 commonly used NSAIDs, dapsone, and enantiomers of flurbiprofen were analyzed for their ability to lower
Ling Rong Wong et al.
The Journal of pharmacy and pharmacology, 70(1), 59-69 (2017-10-17)
R-flurbiprofen (R-FP) was found to offer neuroprotective effects by inhibiting mitochondrial calcium overload induced by β-amyloid peptide toxicity in Alzheimer's disease (AD). However, poor brain penetration after oral administration posed a challenge to its further development for AD treatment. In

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