SML2625
RCM-1
≥98% (HPLC)
동의어(들):
2-[[2-Oxo-2-(2-thienyl)ethyl]thio]-4,6-di-2-thienyl-3-pyridinecarbonitrile, 2-{[2-Oxo-2-(thiophen-2-yl)ethyl]sulfanyl}-4,6-di(thiophen-2-yl)pyridine-3-carbonitrile
로그인조직 및 계약 가격 보기
크기 선택
5 MG
₩143,826
25 MG
₩463,855
모든 사진(1)
크기 선택
보기 변경
5 MG
₩143,826
25 MG
₩463,855
About This Item
실험식(Hill 표기법):
C20H12N2OS4
CAS Number:
Molecular Weight:
424.58
MDL number:
UNSPSC 코드:
12352200
NACRES:
NA.77
추천 제품
![[6]-Gingerol ≥98% (HPLC)](/deepweb/assets/sigmaaldrich/product/structures/259/444/6877889c-1cc0-47f5-b807-f847deadec1d/640/6877889c-1cc0-47f5-b807-f847deadec1d.png)
Quality Level
분석
≥98% (HPLC)
양식
powder
색상
white to very dark orange
solubility
DMSO: 2 mg/mL, clear
저장 온도
2-8°C
SMILES string
[s]1c(ccc1)c2nc(c(c(c2)c4[s]ccc4)C#N)SCC(=O)c3[s]ccc3
InChI key
DCCYTKKDAZEVLY-UHFFFAOYSA-N
생화학적/생리학적 작용
Induces FOXM1 degradation and blocks its nuclear localization, suppresses FOXM1-mediated goblet cell metaplasia and airway hyperresponsiveness in vivo.
RCM-1 is a forkhead box M1 (FOXM1) inhibitor that blocks FOXM1 nuclear localization (IC50 = 720 nM using GFP-FOXM1-expressing U2OS cells) and causes FOXM1 degradation via ubiquitination induction (2.9- and 4.8-fold of basal level in A549 cells with 10 μM or 20 μM RCM-1, respectively) without affecting cellular YAP, FACT140, NF-κB, FOXA2, and FOXJ1 levels. RCM-1 intraperitoneal injection (1.7 mg/kg) in mice downregulates endogenous murine FOXM1 level as well as transgenic human FOXM1 GFP fusion level in vivo, effectively suppressing house dust mite-induced lung inflammation as well as goblet cell metaplasia and airway hyperresponsiveness in response to IL-13.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
Gaohui Wu et al.
Biochemical and biophysical research communications, 495(1), 1432-1439 (2017-11-22)
Functional abnormal airway epithelial cells, along with activated inflammatory cells, resulting in chronic airway inflammation, are considered as the characteristic of asthma. Fatty Acid Binding Protein 4 (FABP4) takes part in glucose and lipid homeostasis, and also have an important
Lifeng Sun et al.
Science signaling, 10(475) (2017-04-20)
Goblet cell metaplasia and excessive mucus secretion associated with asthma, cystic fibrosis, and chronic obstructive pulmonary disease contribute to morbidity and mortality worldwide. We performed a high-throughput screen to identify small molecules targeting a transcriptional network critical for the differentiation
활성 필터
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
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