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Merck
모든 사진(1)

문서

SML2319

Sigma-Aldrich

TAT-Gap19 trifluoroacetate salt

≥95% (HPLC)

동의어(들):

L-Tyrosylglycyl-L-arginyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-glutaminyl-L-arginyl-L-arginyl-L-arginyl-L-lysyl-L-glutaminyl-L-isoleucyl-L-?-glutamyl-L-isoleucyl-L-lysyl-L-lysyl-L-phenylalanyl-L-lysine trifluoroacetate salt, YGRKKRRQRRRKQIEIKKFK trifluoroacetate salt

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About This Item

실험식(Hill 표기법):
C119H212N46O26 · xC2HF3O2
CAS Number:
Molecular Weight:
2703.25 (free base basis)
UNSPSC 코드:
12352200
NACRES:
NA.77

분석

≥95% (HPLC)

형태

lyophilized powder

색상

white to off-white

배송 상태

wet ice

저장 온도

−20°C

생화학적/생리학적 작용

TAT-Gap19 is a cell penetrant analog of a connexin 43 (Cx43) hemichannels selective blocker Gap19. TAT-Gap19 inhibits TAT-Gap19 in mice brain without affecting gap junction channels.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

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문서 라이브러리 방문

Laura Walrave et al.
Frontiers in cellular neuroscience, 10, 288-288 (2017-01-10)
Astrocytes are active players in higher brain function as they can release gliotransmitters, which are essential for synaptic plasticity. Various mechanisms have been proposed for gliotransmission, including vesicular mechanisms as well as non-vesicular ones, for example by passive diffusion via
Verónica Abudara et al.
Frontiers in cellular neuroscience, 8, 306-306 (2014-11-07)
In the brain, astrocytes represent the cellular population that expresses the highest amount of connexins (Cxs). This family of membrane proteins is the molecular constituent of gap junction channels and hemichannels that provide pathways for direct cytoplasm-to-cytoplasm and inside-out exchange
Paolo Bazzigaluppi et al.
Neurobiology of disease, 101, 1-7 (2016-12-23)
Extracellular potassium concentration, [K+]o, is a major determinant of neuronal excitability. In the healthy brain, [K+]o levels are tightly controlled. During seizures, [K+]o increases up to 15mM and is thought to cause seizures due to its depolarizing effect. Although astrocytes
Wei Zhang et al.
Behavioral and brain functions : BBF, 19(1), 23-23 (2023-12-19)
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