SML1637

Hexaminolevulinate hydrochloride

≥98% (HPLC)

• 동의어(들): 5-Aminolevulinic acid hexyl ester HAL hydrochloride, 5-Aminolevulinic acid hexyl ester hydrochloride, HAL, Hexvix, Hexyl 5-aminolevulinate hydrochloride, P 1206, n-Hexyl 5-aminolevulinate hydrochloride
• 실험식(Hill 표기법): C₁₁H₂₁NO₃ · HCl
• CAS Number: 140898-91-5
• Molecular Weight: 251.75
• MDL number: MFCD03695491
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329825978
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 형태: powder
• 저장 조건: desiccated
• 색상: white to beige
• solubility: H₂O: 20 mg/mL, clear
• 저장 온도: room temp
• SMILES string: CCCCCCOC(CCC(CN)=O)=O.[H]Cl
• InChI: 1S/C11H21NO3.ClH/c1-2-3-4-5-8-15-11(14)7-6-10(13)9-12;/h2-9,12H2,1H3;1H
• InChI key: LZYXPFZBAZTOCH-UHFFFAOYSA-N

설명

생화학적/생리학적 작용

Hexaminolevulinate (HAL) hydrochloride is a hexyl ester of 5-Aminolevulinic acid (ALA), a precursor to porphyrins including the photosensitizer protoporphyrin IX (PPIX). Hexaminolevulinate is more lipophilic than ALA, and is 50–100 times more efficient than ALA at inducing PpIX, which accumulates preferentially in neoplastic cells. Hexaminolevulinate administration followed by light activation has been used for fluorescence cystoscopy to enhance detection of bladder cancer, in particular carcinoma in situ (CIS). Hexaminolevulinate is also being studied for use in cancer photodynamic therapy. Hexaminolevulinate followed by irradiation produced DNA oxidative damage and apoptosis.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3