SML1271
TWS119
≥98% (HPLC)
동의어(들):
3-[6-(3-Aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy]phenol
로그인조직 및 계약 가격 보기
크기 선택
5 MG
₩159,761
25 MG
₩641,176
모든 사진(1)
크기 선택
보기 변경
5 MG
₩159,761
25 MG
₩641,176
About This Item
실험식(Hill 표기법):
C18H14N4O2
CAS Number:
Molecular Weight:
318.33
MDL number:
UNSPSC 코드:
12352200
PubChem Substance ID:
NACRES:
NA.77
추천 제품
분석
≥98% (HPLC)
양식
powder
색상
white to beige
solubility
DMSO: 20 mg/mL, clear
저장 온도
2-8°C
SMILES string
OC1=CC(OC2=NC=NC3=C2C=C(C4=CC=CC(N)=C4)N3)=CC=C1
InChI
1S/C18H14N4O2/c19-12-4-1-3-11(7-12)16-9-15-17(22-16)20-10-21-18(15)24-14-6-2-5-13(23)8-14/h1-10,23H,19H2,(H,20,21,22)
InChI key
VPVLEBIVXZSOMQ-UHFFFAOYSA-N
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애플리케이션
TWS119 has been used as glycogen synthase kinase-3β (GSK-3β) GSK3β inhibitor.[1]
생화학적/생리학적 작용
TWS119 favors the γδT cells survival and proliferation by activating the mammalian target of rapamycin (mTOR) pathway.[2] It also promotes the expression of T-cell factor 1 (TCF1) and modulates cytokine production.[3]
TWS119 is a potent Glycogen synthase kinase-3β (GSK-3β) inhibitor that can induce neurogenesis in embryonic stem cells (ESCs).
TWS119 is a potent Glycogen synthase kinase-3β (GSK-3β) inhibitor.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
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시험 성적서(COA)
Lot/Batch Number
이미 열람한 고객
Effects of Glycogen Synthase Kinase-3beta Inhibitor TWS119 on Proliferation and Cytokine Production of TILs From Human Lung Cancer
Tang YY, et al.
Journal of Immunotherapy, 41(7), 319-319 (2018)
Wnt pathway activator TWS119 enhances the proliferation and cytolytic activity of human gammadeltaT cells against colon cancer
Chen YQ, et al.
Experimental Cell Research, 362(1), 63-71 (2018)
Limin Gao et al.
Neuroreport, 35(3), 200-207 (2024-02-02)
Brain injury in preterm infants is a major cause of disability and mortality in children. GSK-3β is a common pathogenic factor for cognitive dysfunction and involves in neuronal proliferation and differentiation. However, GSK-3β affected neuronal differentiation and its molecular pathogenesis
Nurr1: A vital participant in the TLR4-NF-kappaB signal pathway stimulated by alpha-synuclein in BV-2 cells
Shao QH, et al.
Neuropharmacology, 144, 388-399 (2019)
Chen Chen et al.
International immunopharmacology, 85, 106577-106577 (2020-05-24)
Chemokine-like factor 1 (CKLF1) is a chemokine increased significantly in ischemic brain poststroke. It shows chemotaxis effects on various immune cells, but the mechanisms of CKLF1 migrating neutrophils are poorly understood. Recent studies have provided evidence that CC chemokine receptor
활성 필터
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