모든 사진(1)

문서

COO/COA

SML1052

2-D08

Name: 2-D08
Brand: SIGMA

≥98% (HPLC)

동의어(들):

2′,3′,4′-trihydroxy-flavone, 2-(2,3,4-Trihydroxyphenyl)-4H-1-Benzopyran-4-one

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모든 사진(1)

About This Item

실험식(Hill 표기법):

C₁₅H₁₀O₅

CAS Number:

144707-18-6

Molecular Weight:

270.24

UNSPSC 코드:

12352200

NACRES:

NA.77

추천 제품

Slide 1 of 10

1 of 10

Millipore

5.05156

SUMOylation Inhibitor III, 2-D08

Sigma-Aldrich

345887

Ginkgolic Acid (15:1)

Sigma-Aldrich

SMB00129

(15:3)-Anacardic acid

Sigma-Aldrich

A9789

Anisomycin from Streptomyces griseolus

Sigma-Aldrich

SML3360

STM2457

Sigma-Aldrich

S7942

Sirtinol

Sigma-Aldrich

A7236

Anacardic acid

Sigma-Aldrich

5.08197

Ginkgolic Acid (15:1)

Sigma-Aldrich

A9165

N-Acetyl-L-cysteine

Sigma-Aldrich

208795

S-Methyl methanethiosulfonate

Quality Level

100

분석

≥98% (HPLC)

형태

powder

색상

white to beige

solubility

DMSO: 20 mg/mL, clear

저장 온도

2-8°C

애플리케이션

2-D08 has been used as a small ubiquitin-like modifier (SUMO)ylation inhibitor.

생화학적/생리학적 작용

2-D08 is a potent and cell-permeable inhibitor of sumoylation that block the transfer of SUMO (small ubiquitin-like modifier) from the E2 enzyme (Ubc9) thioester conjugate to the substrate.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

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문서 라이브러리 방문

MG132?induced progerin clearance is mediated by autophagy activation and splicing regulation.

Harhouri K, et al.

EMBO Molecular Medicine (2017)

RAS GTPases are modified by SUMOylation.

Choi B H, et al.

Oncotarget, 9(4), 4440-4440 (2018)

MG132-induced progerin clearance is mediated by autophagy activation and splicing regulation.

Karim Harhouri et al.

EMBO molecular medicine, 9(9), 1294-1313 (2017-07-05)

Hutchinson-Gilford progeria syndrome (HGPS) is a lethal premature and accelerated aging disease caused by a de novo point mutation in LMNA encoding A-type lamins. Progerin, a truncated and toxic prelamin A issued from aberrant splicing, accumulates in HGPS cells' nuclei

RAS GTPases are modified by SUMOylation.

Byeong Hyeok Choi et al.

Oncotarget, 9(4), 4440-4450 (2018-02-13)

RAS proteins are GTPases that participate in multiple signal cascades, regulating crucial cellular processes including cell survival, proliferation, differentiation, and autophagy. Mutations or deregulated activities of RAS are frequently the driving force for oncogenic transformation and tumorigenesis. Given the important

2-D08 as a SUMOylation inhibitor induced ROS accumulation mediates apoptosis of acute myeloid leukemia cells possibly through the deSUMOylation of NOX2.

Pan Zhou et al.

Biochemical and biophysical research communications, 513(4), 1063-1069 (2019-04-24)

Acute myeloid leukemia (AML) is a heterogeneous clonal hematopoietic malignancy with poor survival and frequent relapse. Recently, a posttranslational modification of proteins with small ubiquitin-like modifiers (SUMO) has been notably implicated in a wide spectrum of diseases, especially cancers. Ubc9

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DISCOVER Bioactive Small Molecules for Nitric Oxide & Cell Stress Research

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2-D08

≥98% (HPLC)

About This Item

추천 제품

속성

Quality Level

분석

형태

색상

solubility

저장 온도

설명

애플리케이션

생화학적/생리학적 작용

안전성 정보

Storage Class Code

WGK

Flash Point (°F)

Flash Point (°C)

문서

시험 성적서(COA)

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