SML0442

ML239

≥98% (HPLC)

• 동의어(들): (2,4,6-Trichloro-phenoxy)-acetic acid (1H-pyrrol-2-ylmethylene)-hydrazide
• 실험식(Hill 표기법): C₁₃H₁₀Cl₃N₃O₂
• CAS Number: 1378872-36-6
• Molecular Weight: 346.60
• MDL number: MFCD23098913
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329824724
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to beige
• solubility: DMSO: 15 mg/mL (clear solution)
• 저장 온도: 2-8°C
• SMILES string: Clc1cc(Cl)c(OCC(=O)N\N=C\c2ccc[nH]2)c(Cl)c1
• InChI: 1S/C13H10Cl3N3O2/c14-8-4-10(15)13(11(16)5-8)21-7-12(20)19-18-6-9-2-1-3-17-9/h1-6,17H,7H2,(H,19,20)/b18-6+
• InChI key: NVEDPFICKAIHKD-NGYBGAFCSA-N

설명

애플리케이션

ML239 has been used as a proble in cellular lipid profiling.[1]

생화학적/생리학적 작용

ML239 decreases the saturated and monounsaturated lysophosphatidylethanolamines in lung cancer cells and is toxic to breast cancer cells.[1] ML239 may elicit toxicity by modulating the nuclear factor−κB (NF-κB) associated pathways.[2]

ML239 is an inhibitor of breast cancer stem cells found from a screen using stem cell-like human mammary epithelial cells (HMLE). ML239 inhibited cancer stem cells with an IC₅₀ of 1.16 μM with 24-fold selectivity against the control cell line.

ML239 is an inhibitor of breast cancer stem cells.

안전성 정보

• 픽토그램: GHS07,GHS09
• 신호어: Warning
• 유해 및 위험 성명서: H302 + H312 + H332,H315,H319,H335,H400
• 예방조치 성명서: P273 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Acute 1 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 표적 기관: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable