SML0393

QNZ46

≥98% (HPLC)

• 동의어(들): 4-[6-Methoxy-2-[(1E)-2-(3-nitrophenyl)ethenyl]-4-oxo-3(4H)-quinazolinyl]-Benzoic acid
• 실험식(Hill 표기법): C₂₄H₁₇N₃O₆
• CAS Number: 1237744-13-6
• Molecular Weight: 443.41
• MDL number: MFCD22666391
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329825390
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 형태: powder
• 색상: white to beige
• solubility: DMSO: 5 mg/mL (warmed; clear solution)
• 저장 온도: room temp
• SMILES string: COc1ccc2N=C(\C=C\c3cccc(c3)[N+]([O-])=O)N(C(=O)c2c1)c4ccc(cc4)C(O)=O
• InChI: 1S/C24H17N3O6/c1-33-19-10-11-21-20(14-19)23(28)26(17-8-6-16(7-9-17)24(29)30)22(25-21)12-5-15-3-2-4-18(13-15)27(31)32/h2-14H,1H3,(H,29,30)/b12-5+
• InChI key: GNLVJIICVWDSNI-LFYBBSHMSA-N

설명

생화학적/생리학적 작용

QNZ46 is a noncompetitive inhibitor of GluN2C/D containing NMDA receptors. KD and IC₅₀ values for binding and inhibition of GluN1/Glun2D receptors by QNZ46 are 4.9 and 3.9 μM, respectively. QNZ46 does not compete for binding of glutamate or glycine, but QNZ46 receptor binding requires the binding of glutamate to the GluN2 subunit.

특징 및 장점

This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable