SML0350
AZD-7762 hydrochloride
≥98% (HPLC)
동의어(들):
5-(3-Fluorophenyl)-3-ureidothiophene-2-carboxylic acid N-[(S)-piperidin-3-yl]amide hydrochloride, AZD 7762 hydrochloride
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모든 사진(1)
크기 선택
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5 MG
₩208,786
25 MG
₩638,638
About This Item
실험식(Hill 표기법):
C17H19FN4O2S · HCl
CAS Number:
Molecular Weight:
398.88
MDL number:
UNSPSC 코드:
12352200
PubChem Substance ID:
NACRES:
NA.77
추천 제품
분석
≥98% (HPLC)
양식
powder
저장 조건
desiccated
색상
white to light brown
solubility
DMSO: 15 mg/mL, clear
저장 온도
−20°C
SMILES string
Cl.NC(=O)Nc1cc(sc1C(=O)N[C@H]2CCCNC2)-c3cccc(F)c3
InChI
1S/C17H19FN4O2S.ClH/c18-11-4-1-3-10(7-11)14-8-13(22-17(19)24)15(25-14)16(23)21-12-5-2-6-20-9-12;/h1,3-4,7-8,12,20H,2,5-6,9H2,(H,21,23)(H3,19,22,24);1H/t12-;/m0./s1
InChI key
WFZBLOIXZRZEDG-YDALLXLXSA-N
애플리케이션
AZD-7762 hydrochloride has been used:
- as a checkpoint kinase 1 and 2 (CHK1/2) inhibitor to study its effect on the efficiency of non-homologous end-joining (NHEJ) repair in breast cancer cell lines[1]
- as a CHK1 inhibitor to serve as a positive control for replication stress in the assessment of fork restart events[2]
- as a CHK1/2 inhibitor to study its effects on DNA lesions during mice zygote development[3]
생화학적/생리학적 작용
AZD-7762 is a potent, ATP-competitive inhibitor of Chk1 and Chk2 that enhanced cytotoxicity DNA-damaging agents.
AZD-7762 is a potent, ATP-competitive inhibitor of Chk1 and Chk2.
신호어
Danger
유해 및 위험 성명서
Hazard Classifications
Acute Tox. 4 Oral - Eye Dam. 1
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
시험 성적서(COA)
Lot/Batch Number
Peter Tonzi et al.
eLife, 7 (2018-11-14)
DNA replication stress is often defined by the slowing or stalling of replication fork progression leading to local or global DNA synthesis inhibition. Failure to resolve replication stress in a timely manner contribute toward cell cycle defects, genome instability and
Sabrina Ladstätter et al.
Cell, 167(7), 1774-1787 (2016-12-06)
Sexual reproduction culminates in a totipotent zygote with the potential to produce a whole organism. Sperm chromatin reorganization and epigenetic reprogramming that alter DNA and histone modifications generate a totipotent embryo. Active DNA demethylation of the paternal genome has been
Andrea M Pesch et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 26(24), 6568-6580 (2020-09-25)
Cyclin-dependent kinase 4/6 (CDK4/6) inhibitors have improved progression-free survival for metastatic, estrogen receptor-positive (ER+) breast cancers, but their role in the nonmetastatic setting remains unclear. We sought to understand the effects of CDK4/6 inhibition (CDK4/6i) and radiotherapy in multiple preclinical
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