The trigeminovascular nociception induced by electrical stimulation of the dura mater surrounding the superior sagittal sinus in anesthetized animals has been widely used as a model for investigation of the pathophysiology of vascular headache such as migraine. However, little is
To examine total migraine freedom (TMF), defined as pain freedom and absence of associated symptoms, using rizatriptan clinical trial data and to explore advantages of TMF as a single primary composite efficacy endpoint. The FDA has set a higher regulatory
To evaluate the pharmacokinetic profile and tolerability of single doses of rizatriptan oral disintegrating tablets (ODTs) in pediatric migraineurs. Acute migraine treatment options for children are limited despite a rising migraine prevalence. No triptans are approved in those under 12
