SML0187

CJ-13610

≥98% (HPLC)

• 동의어(들): Tetrahydro-4-[3-[[4-(2-methyl-1H-imidazol-1-yl)phenyl]thio]phenyl]-2H-pyran-4-carboxamide
• 실험식(Hill 표기법): C₂₂H₂₃N₃O₂S
• CAS Number: 179420-17-8
• Molecular Weight: 393.50
• MDL number: MFCD00948114
• UNSPSC 코드: 51111800
• PubChem Substance ID: 329825216
• NACRES: NA.77

속성

• 분석: ≥98% (HPLC)
• 양식: powder
• 저장 조건: desiccated
• 색상: white to tan
• solubility: DMSO: ≥10 mg/mL
• 저장 온도: 2-8°C
• SMILES string: Cc1nccn1-c2ccc(Sc3cccc(c3)C4(CCOCC4)C(N)=O)cc2
• InChI: 1S/C22H23N3O2S/c1-16-24-11-12-25(16)18-5-7-19(8-6-18)28-20-4-2-3-17(15-20)22(21(23)26)9-13-27-14-10-22/h2-8,11-12,15H,9-10,13-14H2,1H3,(H2,23,26)
• InChI key: VPTONMHDLLMOOV-UHFFFAOYSA-N

설명

애플리케이션

CJ-13610 may be used to study 5-lipoxygenase-mediated cell signaling.

생화학적/생리학적 작용

CJ-13,610 is a potent inhbititor of 5-lipoxygenase (5-LO) activity (IC₅₀ = 70 nM).

CJ-13610 inhibits the biosynthesis of leukotriene B4 and regulates the IL-6 mRNA expression in macrophages. It reduces fibrosis and necroinflammation of liver in carbon tetrachloride-treated mice.[1]

Potent 5-lipoxygenase inhibitor

특징 및 장점

This compound is featured on the Leukotriene Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable