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Merck
모든 사진(2)

문서

SMB00472

Sigma-Aldrich

Palmatine chloride

≥98% (HPLC)

동의어(들):

Berbinium, Dibenzo[a,g]quinolizinium,5,6-dihydro-2,3,9,10-tetramethoxychloride, Fibrauretin chloride

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About This Item

실험식(Hill 표기법):
C21H22ClNO4
CAS Number:
Molecular Weight:
387.86
MDL number:
UNSPSC 코드:
12352205
PubChem Substance ID:
NACRES:
NA.25

Quality Level

분석

≥98% (HPLC)

형태

powder

응용 분야

metabolomics
vitamins, nutraceuticals, and natural products

배송 상태

wet ice

저장 온도

−20°C

SMILES string

COC1=CC2=C(C=C1OC)CC[N+]3=CC4=C(OC)C(OC)=CC=C4C=C32.[Cl-]

InChI

1S/C21H22NO4.ClH/c1-23-18-6-5-13-9-17-15-11-20(25-3)19(24-2)10-14(15)7-8-22(17)12-16(13)21(18)26-4;/h5-6,9-12H,7-8H2,1-4H3;1H/q+1;/p-1

InChI key

RLQYRXCUPVKSAW-UHFFFAOYSA-M

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일반 설명

Palmatineis an isoquinoline alkaloid. Palmatine chloride (PMTCl) is a protoberberine isoquinoline alkaloid with no ketone group and a soluble drug form of palmatine. It has low hygroscopic stability because of chloride ions present in its structure. PMTCl is a natural compound found in the rhizomes of Coptischinensis.

애플리케이션

Palmatine chloride has been used to test its effects as an inhibitor of soluble epoxide hydrolase (sEH) in vitro.

생화학적/생리학적 작용

Palmatine chloride acts as a microbial collagenase inhibitor and a potential anti-infective agent. It possesses many other pharmacological properties such as antioxidant, anti-inflammatory, anticancer, anti-viral, and neuroprotective.

픽토그램

Exclamation mark

신호어

Warning

유해 및 위험 성명서

예방조치 성명서

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

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문서 라이브러리 방문

Georgiana Nitulescu et al.
Life (Basel, Switzerland), 12(12) (2022-12-24)
Bacterial virulence factors are mediating bacterial pathogenesis and infectivity. Collagenases are virulence factors secreted by several bacterial stains, such as Clostridium, Bacillus, Vibrio and Pseudomonas. These enzymes are among the most efficient degraders of collagen, playing a crucial role in
Improving hygroscopic stability of palmatine chloride by forming a pharmaceutical salt cocrystal of palmatine chloride-gallic acid with neutral molecule
Zhang YN, et al.,
Journal of drug delivery science and technology, 66, 102839-102839 (2021)
Jang Hoon Kim et al.
Current issues in molecular biology, 44(9), 4282-4289 (2022-09-23)
The quaternary isoquinoline alkaloids of palmatine (1), berberine (2), and jatrorrhizine (3) were evaluated in terms of their ability to inhibit soluble epoxide hydrolase (sEH). They had similar inhibitory activities, with IC50 values of 29.6 ± 0.5, 33.4 ± 0.8

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