SMB00376

CDDO Methyl Ester

≥98% (HPLC)

• 동의어(들): 2-Cyano-3,12-dioxo-oleana-1,9(11)-dien-28-oic acid methyl ester, Bardoxolone Methyl, CDDO-Me
• 실험식(Hill 표기법): C₃₂H₄₃NO₄
• CAS Number: 218600-53-4
• Molecular Weight: 505.69
• MDL number: MFCD11983137
• UNSPSC 코드: 12352205
• PubChem Substance ID: 329824977
• NACRES: NA.25

속성

• Quality Level: 200
• 분석: ≥98% (HPLC)
• 양식: powder
• 응용 분야: metabolomics; vitamins, nutraceuticals, and natural products
• 저장 온도: −20°C
• SMILES string: CC1(C)CC[C@]2(C(OC)=O)CC[C@@]([C@@]3([H])[C@]2([H])C1)(C)[C@]4(C)CC[C@@]5([H])C(C)(C)C(C(C#N)=C[C@]5(C)C4=CC3=O)=O
• InChI: 1S/C32H43NO4/c1-27(2)11-13-32(26(36)37-8)14-12-31(7)24(20(32)17-27)21(34)15-23-29(5)16-19(18-33)25(35)28(3,4)22(29)9-10-30(23,31)6/h15-16,20,22,24H,9-14,17H2,1-8H3/t20-,22-,24-,29-,30+,31+,32-/m0/s1
• InChI key: WPTTVJLTNAWYAO-KPOXMGGZSA-N
• 유전자 정보: human ... IKBKB(3551) , KEAP1(9817) , NFE2L2(4780) , PPARG(5468)

설명

일반 설명

CDDO-Me is a synthetic triterpenoid compound with anti-inflammatory, anti-tumor and cytoprotective properties.[1] It is derived from the natural product oleanic acid.[2]

애플리케이션

CDDO Methyl Ester has been used to test its effect on hepatocyte membrane transporters (HMTs) regulation and mitigation of cholestasis in hepatic ischemia-reperfusion injury (IRI).[3] It has also been used activator of NF E2 Related Factor 2 (NRF2) to study its role in preventing cell death in melanoma cells.[4]

생화학적/생리학적 작용

CDDO-Me inhibits inflammatory mediators including interleukin-6 (IL-6), IL-10, and IL-12. It enhances apoptosis induced by TNF and chemotherapeutic agents.[5] CDDO-Me exhibits anti-proliferative activity in osteosarcoma cells and enhances the effectiveness of chemotherapeutic agents by inducing an intrinsic mitochondrial-dependent apoptotic pathway. It can be used as an adjuvant treatment for advanced and fatal form of prostate cancer.[5]

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable