SMB00286
Terconazole
≥98%
동의어(들):
(+-)-1-{4-[cis-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethoxy]phenyl}-4-isopropylpiperazine, Triaconazole
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모든 사진(1)
About This Item
실험식(Hill 표기법):
C26H31Cl2N5O3
CAS Number:
Molecular Weight:
532.46
EC Number:
UNSPSC 코드:
51303407
NACRES:
NA.85
추천 제품
분석
≥98%
양식
powder
색상
white
solubility
DMSO: 1 mg/mL
항생제 활성 스펙트럼
fungi
동작 모드
enzyme | interferes
저장 온도
2-8°C
InChI
1S/C26H31Cl2N5O3/c1-19(2)31-9-11-32(12-10-31)21-4-6-22(7-5-21)34-14-23-15-35-26(36-23,16-33-18-29-17-30-33)24-8-3-20(27)13-25(24)28/h3-8,13,17-19,23H,9-12,14-16H2,1-2H3/t23-,26-/m0/s1
InChI key
BLSQLHNBWJLIBQ-OZXSUGGESA-N
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일반 설명
Terconazole is a traizole ketal derivative, which is antifungal in nature. It is especially effective against Candidal spp.[1]
애플리케이션
생화학적/생리학적 작용
Terconazole suppresses the growth of various types of yeats and mycelium-forming fungi in in vitro conditions. Its antifungal activity is an outcome of the accumulation of the membrane-disrupting 14α-demethylsterols and ergosterol depletion. This is result of inactivation of cytochrome P-450-dependent 14α-demethylase by terconazole.[1] It is a rapidly-acting and well-tolerated antifungal used for the treatment of vulvovaginal candidiasis.[4] It is also used for the treatment of dermatophytosis and candidosis.[5] The drug may facilitate the accumulation of cholesterol in late endosomes.[3]
포장
2MG
저장 및 안정성
Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): Non Combustible Solids
기타 정보
Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place. Storage class (TRGS 510): Non Combustible Solids
신호어
Warning
유해 및 위험 성명서
Hazard Classifications
Aquatic Chronic 4 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
표적 기관
Respiratory system
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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이미 열람한 고객
J Van Cutsem et al.
Chemotherapy, 29(5), 322-331 (1983-01-01)
Terconazole, a new triazole ketal, is found to be highly active in vitro on a wide range of yeasts and mycelium-forming fungi. The in vitro activity depends largely on the medium used. In vitro it is a potent antifungal agent
Heike Hofmann-Winkler et al.
The Journal of infectious diseases, 212 Suppl 2, S172-S180 (2015-04-04)
The ongoing Ebola virus (EBOV) disease (EVD) epidemic in Western Africa is the largest EVD outbreak recorded to date and requires the rapid development and deployment of antiviral measures. The viral glycoprotein (GP) facilitates host cell entry and, jointly with
E L Tolman et al.
Antimicrobial agents and chemotherapy, 29(6), 986-991 (1986-06-01)
Terconazole is a new triazole ketal derivative with broad-spectrum in vitro and in vivo antifungal activities. This study further characterizes the effects of terconazole in vitro on yeast cell growth, viability, and morphology. Terconazole inhibited the growth of Candida albicans
Florian Wrensch et al.
Viruses, 6(9), 3683-3698 (2014-09-27)
The interferon-inducible transmembrane (IFITM) proteins 1, 2 and 3 inhibit the host cell entry of several enveloped viruses, potentially by promoting the accumulation of cholesterol in endosomal compartments. IFITM3 is essential for control of influenza virus infection in mice and
Ting Li et al.
Medical mycology, 53(5), 455-461 (2015-04-17)
Terconazole is a new, broad-spectrum, triazole antifungal agent. The aim of this study was to compare the efficacy and safety of a 6-day course of a terconazole vaginal suppository (80 mg) with two doses of oral fluconazole (150 mg) for
활성 필터
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