Sodium voltage-gated channel α subunit 2 (SCN2A1) is expressed in the axons and nerve terminals of the rat brain. The gene ID for the protein is 24766.
특이성
Detects ~250 kDa.
면역원
Fusion protein amino acids 1882-2005 (cytoplasmic C-terminus) of rat Nav1.2
Monoclonal anti-SCN2A1 antibody produced in mouse has been used for immunofluorescence and Western blotting.[1]
생화학적/생리학적 작용
Sodium voltage-gated channel α subunit 2 (SCN2A1) may associate with a number of other proteins in the rat brain. It regulates the conductance of action potentials and also controls the release of neurotransmitters.
특징 및 장점
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물리적 형태
Solution in PBS, pH 7.4, 50% glycerol, and 0.09% sodium azide
면책조항
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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시험 성적서(COA)
Lot/Batch Number
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Voltage-gated sodium channels (Nav1.1-Nav1.9) are responsible for the initiation and propagation of action potentials in neurons, controlling firing patterns, synaptic transmission and plasticity of the brain circuit. Yet, it is the protein-protein interactions of the macromolecular complex that exert diverse
The Journal of biological chemistry, 289(22), 15363-15373 (2014-04-17)
Voltage-gated sodium (Nav) channels initiate action potentials in brain neurons and are primary therapeutic targets for anti-epileptic drugs controlling neuronal hyperexcitability in epilepsy. The molecular mechanisms underlying abnormal Nav channel expression, localization, and function during development of epilepsy are poorly
Molecular medicine reports, 9(1), 16-22 (2013-11-14)
In order to evaluate SCN2A as a candidate gene for epileptic susceptibility and the use of a Cu-Zn superoxide dismutase (SOD) supplement as a potential therapy for epilepsy, SCN2A expression in the cortex and the correlation between SCN2A and Cu-Zn
질문
후기
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