SAB4700632
Monoclonal Anti-HLA Class I antibody produced in mouse
clone MEM-81, purified immunoglobulin, buffered aqueous solution
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크기 선택
100 μG
₩375,956
₩375,956
예상 입고일2025년 8월 25일세부사항
기존과 동일한 품질을 인하된 가격으로 - 어려운 예산 상황을 머크와 함께 극복하세요
모든 사진(1)
크기 선택
보기 변경
100 μG
₩375,956
About This Item
UNSPSC 코드:
12352203
NACRES:
NA.41
₩375,956
예상 입고일2025년 8월 25일세부사항
기존과 동일한 품질을 인하된 가격으로 - 어려운 예산 상황을 머크와 함께 극복하세요
추천 제품
생물학적 소스
mouse
Quality Level
결합
unconjugated
항체 형태
purified immunoglobulin
항체 생산 유형
primary antibodies
클론
MEM-81, monoclonal
양식
buffered aqueous solution
종 반응성
human
농도
1 mg/mL
기술
flow cytometry: suitable
동형
IgG1
NCBI 수납 번호
UniProt 수납 번호
배송 상태
wet ice
저장 온도
2-8°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... HLA-A(3105) , HLA-B(3106) , HLA-C(3107)
관련 카테고리
일반 설명
Human leukocyte antigen A classical class I family consists of three members including HLA-A, HLA-B and HLA-C. Members of classical class I major histocompatibility complex (MHC) contain a peptide bound to a transmembrane glycoprotein subunit, the heavy chain, in association with a soluble light chain called β2-microglobulin. Class I MHC are present in changeable volumes on all nucleated cells.
The antibody MEM-81 reacts with human classical MHC Class I molecules in native cell-surface forms. MHC Class I molecules (MHC Class Ia) are expressed on the surface of human nucleated cell types.
The previously assigned protein identifier P01891 has been merged into P04439. Full details can be found on the UniProt database.
The previously assigned protein identifier P01891 has been merged into P04439. Full details can be found on the UniProt database.
면역원
Leukocytes of a patient suffering with LGL type leukemia
애플리케이션
The reagent is designed for Flow Cytometry analysis. Suggested working dilution for Flow Cytometry is 1 μg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.
생화학적/생리학적 작용
Human leukocyte antigen A class I downregulation is implicated in tumor invasion and development. Genetic variations in the class I major histocompatibility complex (MHC) is associated with the development of melanoma. HLA-viral peptide interaction plays a major role in the regulation of human immunodeficiency virus (HIV) infection.
특징 및 장점
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
물리적 형태
Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.
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Storage Class Code
10 - Combustible liquids
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
Genes regulating HLA class I antigen expression in T-B lymphoblast hybrids
Salter RD
Immunogenetics, 21, 235-246 (1985)
The Major Genetic Determinants of HIV-1 Control Affect HLA Class I Peptide Presentation
Pereyra F
Science, 330, 1551-1557 (2010)
Implications for immunosurveillance of altered HLA class I phenotypes in human tumours.
Garrido F
Immunology Today, 18, 89-95 (1997)
Loss of HLA class I antigens by melanoma cells: molecular mechanisms, functional significance and clinial relevance
Ferrone S and Marincola FM
Immunology Today, 16, 487-494 (1995)
Recognition of human histocompatibility leukocyte antigen (HLA)-E complexed with HLA class I signal sequence-derived peptides by CD94/NKG2 confers protection from natural killer cell-mediated lysis.
Borrego F
The Journal of Experimental Medicine, 187, 813-818 (1998)
활성 필터
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
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