SAB4504517

Anti-phospho-PKR (pThr⁴⁴⁶) antibody produced in rabbit

affinity isolated antibody

• 동의어(들): Anti-DYT33, Anti-EIF2AK1, Anti-LEUDEN, Anti-PKR, Anti-PPP1R83, Anti-PRKR
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• 결합: unconjugated
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 형태: buffered aqueous solution
• 분자량: antigen 62 kDa
• 종 반응성: rat, human, mouse
• 농도: ~1 mg/mL
• 기술: ELISA: 1:10000; western blot: 1:500-1:1000
• NCBI 수납 번호: P19525
• UniProt 수납 번호: P19525
• 배송 상태: wet ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: phosphorylation (pThr446)
• 유전자 정보: human ... EIF2AK2(5610)

설명

일반 설명

EIF2AK2 (eukaryotic translation initiation factor 2α kinase 2) is an intracellular protein, that is also called as RNA-dependent protein kinase (PKR). It belongs to the eIF2αfamily of protein kinases. PKR contains two RNA binding domains and a kinase domain. This gene is located on human chromosome 2p22-p21.

면역원

The antiserum was produced against synthesized peptide derived from human PKR around the phosphorylation site of Thr446.

Immunogen Range: 413-462

생화학적/생리학적 작용

EIF2AK2 (eukaryotic translation initiation factor 2 α kinase 2) plays a key role in antiviral response promoted by interferons. This gene is involved in stress responses and inflammation pathways. This gene controls the development and multiplication of cells, nutrient signaling and metabolism. EIF2AK2 also participates in several cell regulatory pathways like antiviral activity, growth suppression, transcriptional regulation and apoptosis.

특징 및 장점

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물리적 형태

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable