SAB4504289

Anti-phospho-p47 phox (pSer³⁵⁹) antibody produced in rabbit

affinity isolated antibody

• 동의어(들): Anti-CGD1, Anti-NCF1A, Anti-NOXO2, Anti-SH3PXD1A, Anti-p47phox
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 100
• 결합: unconjugated
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 양식: buffered aqueous solution
• 분자량: antigen 44 kDa
• 종 반응성: rat, mouse, human
• 농도: ~1 mg/mL
• 기술: ELISA: 1:5000; immunofluorescence: 1:100-1:500; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000
• NCBI 수납 번호: P14598
• UniProt 수납 번호: P14598
• 배송 상태: wet ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: phosphorylation (pSer359)
• 유전자 정보: human ... NCF1(653361)

설명

일반 설명

Phospho-p47/ NCF1 (neutrophil cytosolic factor-1) codes for the p47^phox subunit of the phagocyte NADPH oxidase (NOX2). It is a cytosolic factor. This gene is located with two pseudogenes (NCF1B and NCF1C). NCF1 is mapped to human chromosome 7q11.23.

면역원

The antiserum was produced against synthesized peptide derived from human p47 phox around the phosphorylation site of Ser359.

Immunogen Range: 331-380

생화학적/생리학적 작용

NCF1 (neutrophil cytosolic factor-1) is an important constituent of the phagocyte NADPH-oxidase system. The enzyme helps in the synthesis of microbicidal superoxide in phagocytes like neutrophil and plays a key role in host defense against microbial pathogens. A 2-bp GT deletion in exon 2 of the NCF1 gene results in chronic granulomatous disease (CGD).

특징 및 장점

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물리적 형태

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable