₩597,429
예상 입고일2025년 6월 18일세부사항
기존과 동일한 품질을 인하된 가격으로 - 어려운 예산 상황을 머크와 함께 극복하세요
생물학적 소스
rabbit
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
양식
buffered aqueous solution
분자량
antigen 52 kDa
종 반응성
mouse, human, rat
농도
~1 mg/mL
기술
ELISA: 1:10000
western blot: 1:500-1:1000
NCBI 수납 번호
UniProt 수납 번호
응용 분야
research pathology
배송 상태
wet ice
저장 온도
−20°C
타겟 번역 후 변형
phosphorylation (pSer250)
유전자 정보
human ... SMAD2(4087)
일반 설명
SMAD2 (SMAD family member 2) is also called as MADR2 (substrate of the TGFβ receptor). It is located on human chromosome 18q21. This gene belongs to the mothers against Dpp (MAD) related family of proteins. SMAD2 has two highly conserved amino and carboxyl-terminal domains (MH1 and MH2 domains) but has no known structural motifs.
면역원
The antiserum was produced against synthesized peptide derived from human Smad2 around the phosphorylation site of Ser250.
Immunogen Range: 216-265
Immunogen Range: 216-265
애플리케이션
Anti-phospho-Smad2 (pSer250) antibody has been used in immunoblotting.
생화학적/생리학적 작용
SMAD2 (SMAD family member 2) plays an important role in TGF-β(transforming growth factor β)/activin signaling pathways. Mutations in SMAD2 (SMAD family member 2) results in arterial aneurysms and dissections. Upregulation of Smad2 blocks the multiplication of gingival epithelial cells. Smad2 positively and negatively controls TGFβ-dependent transcription with the help of forkhead DNA-binding protein FAST2.
특징 및 장점
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
물리적 형태
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
Frequency of Smad Gene Mutations in Human Cancers'
Riggins G J, et al.
Cancer Research (1997)
Smad2 and Smad3 Positively and Negatively Regulate TGF?-Dependent Transcription through the Forkhead DNA-Binding Protein FAST2
Labbe E, et al.
Molecular Cell, 2, 109-120 (1998)
Cytoplasmic PML promotes TGF-?-associated epithelial-mesenchymal transition and invasion in prostate cancer
Buczek ME, et al.
Oncogene, 35(26), 3465-3475 (2016)
SMAD2 Mutations Are Associated with Arterial Aneurysms and Dissections
Micha D, et al.
Human Mutation, 36(12), 1145-1149 (2015)
Overexpression of Smad2 inhibits proliferation of gingival epithelial cells
Shimoe M, et al.
Journal of Periodontal Research, 49(3), 290-298 (2014)
활성 필터
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
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