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예상 입고일2025년 7월 14일세부사항
기존과 동일한 품질을 인하된 가격으로 - 어려운 예산 상황을 머크와 함께 극복하세요
추천 제품
생물학적 소스
rabbit
Quality Level
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
양식
buffered aqueous solution
분자량
antigen 47 kDa
종 반응성
rat, human, mouse
농도
~1 mg/mL
기술
ELISA: 1:1000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI 수납 번호
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
타겟 번역 후 변형
phosphorylation (pSer412)
유전자 정보
human ... ARRB1(408)
일반 설명
Arrestin 1 (ARRB1) is also termed as β-arrestin-1. This is a cytoplasmic adaptor protein located on human chromosome 11q13.
면역원
The antiserum was produced against synthesized peptide derived from human Arrestin 1 around the phosphorylation site of Ser412.
Immunogen Range: 369-418
Immunogen Range: 369-418
생화학적/생리학적 작용
Arrestin 1 (ARRB1) participates in DNA damage accumulation and cell apoptosis. Deletion of ARRB1 blocks DDR (DNA damage response) pathway activation. During hypoxia, ARRB1 controls breast cancer cell survival with the help of HIF-1 transcription factor. This gene can act as a scaffold and an adaptor in receptor endocytosis and signal transduction.
특징 및 장점
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
물리적 형태
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
?-arrestin1 over-expression is associated with an unfavorable prognosis in lung adenocarcinomas and correlated with vascular endothelial growth factor
Qiu C, et al.
International Journal of Clinical and Experimental Pathology, 8(4), 3785-3793 (2015)
ARRB1/?-arrestin-1 mediates neuroprotection through coordination of BECN1-dependent autophagy in cerebral ischemia
Wang P, et al.
Autophagy, 10(9), 1535-1548 (2014)
Assignment of the beta-arrestin 1 gene (ARRB1) to human chromosome 11q13
Calabrese G, et al.
Genomics, 24(1), 169-171 (1994)
ARRB1 enhances the chemosensitivity of lung cancer through the mediation of DNA damage response
Shen H, et al.
Oncology Reports, 37(2), 761-767 (2017)
활성 필터
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