SAB4503802

Anti-phospho-BTK (pTyr⁵⁵¹) antibody produced in rabbit

affinity isolated antibody

• 동의어(들): Anti-AGMX1, Anti-AT, Anti-ATK, Anti-BPK, Anti-IGHD3, Anti-IMD1, Anti-PSCTK1, Anti-XLA
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 100
• 결합: unconjugated
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 양식: buffered aqueous solution
• 분자량: antigen 76 kDa
• 종 반응성: rat, human, mouse
• 농도: ~1 mg/mL
• 기술: ELISA: 1:40000; western blot: 1:500-1:1000
• NCBI 수납 번호: Q06187
• UniProt 수납 번호: Q06187
• 배송 상태: wet ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: phosphorylation (pTyr551)
• 유전자 정보: human ... BTK(695)

설명

일반 설명

Bruton tyrosine kinase (BTK) is encoded by the gene mapped to human chromosome Xq22. The encoded protein belongs to the Tec family of kinases.

면역원

The antiserum was produced against synthesized peptide derived from human BTK around the phosphorylation site of Tyr551.

Immunogen Range: 516-565

생화학적/생리학적 작용

Bruton tyrosine kinase (BTK) is a key element of B-cell–receptor signaling, which facilitates interactions with the tumor microenvironment and stimulates the survival and proliferation of chronic lymphocytic leukemia (CLL) cells. The encoded protein also plays a crucial role in activation of various constitutively active pathways of CLL-cell survival, such as the Akt, extracellular signal-regulated kinase (ERK) and nuclear factor κ light-chain enhancer of activated B cells (NF-κB) pathways. Additionally, it is also necessary for chemokine-mediated homing and adhesion of B cells. Polymorphisms in the gene are associated with the development of a symptomatic primary antibody deficiency (PAD), X-linked agammaglobulinemia.

특징 및 장점

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물리적 형태

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable